Evidence map›Paper›PMID 23591432›Full record

GuidelinePancreas2013

Consensus guidelines for the management and treatment of neuroendocrine tumors.

Pamela L Kunz, Diane Reidy-Lagunes, Lowell B Anthony, Erin M Bertino, Kari Brendtro, Jennifer A Chan, Herbert Chen, Robert T Jensen, Michelle Kang Kim, David S Klimstra and 8 more

Open access · greenAbstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in Pancreas, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 4 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 4 syntheses or guidelines pooled it, 584 citations in OpenAlex.

  1. Pooled it
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  15. Size matters: Establishing a cut-off for rectal neuroendocrine neoplasm to predict recurrence and standardize surveillance guidelines.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Article
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  20. Review

205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Pamela L KunzDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5826, USA pkunz@stanford.edu
Diane Reidy-Lagunes
Lowell B Anthony
Erin M Bertino
Kari Brendtro
Jennifer A Chan
Herbert Chen
Robert T Jensen
Michelle Kang Kim
David S Klimstra
Matthew H Kulke
Eric H Liu
David C Metz
Alexandria T Phan
Rebecca S Sippel
Jonathan R Strosberg
James C Yao
North American Neuroendocrine Tumor Society
Memorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USThe University of Texas MD Anderson Cancer Center · USDana-Farber Cancer Institute · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USVanderbilt University · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Diagnosis, Natural History, Management,tumor biology of Gastrinomas/PETs/Neuroendocrine tumorsZIADK053200 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 2009 to 2025
$4.3M
Molecular and Genetic Analysis of Neuroendocrine Tumor Risk and SurvivalR01CA151532 · NCI · DANA-FARBER CANCER INST · PI KULKE, MATTHEW H · 2011 to 2014
$2.4M
NCI NIH HHS K12 CA090625NCI NIH HHS R01 CA151532
6 · The paper itself

Abstract

Neuroendocrine tumors are a heterogeneous group of tumors originating in various anatomic locations. The management of this disease poses a significant challenge because of the heterogeneous clinical presentations and varying degrees of aggressiveness. The recent completion of several phase 3 trials, including those evaluating octreotide, sunitinib, and everolimus, demonstrate that rigorous evaluation of novel agents in this disease is possible and can lead to practice-changing outcomes. Nevertheless, there are many aspects to the treatment of neuroendocrine tumors that remain unclear and controversial. The North American Neuroendocrine Tumor Society published a set of consensus guidelines in 2010, which provided an overview for the treatment of patients with these malignancies. Here, we present a set of consensus tables intended to complement these guidelines and serve as a quick, accessible reference for the practicing physician.

Indexed as

Biomarkers, TumorHumansMolecular Targeted TherapyNeuroendocrine TumorsNorth AmericaSocieties, MedicalBiomarkers, Tumor

Identifiers

PMID23591432
PMCPMC4304762
OpenAlexW2071272233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.