ArticleThe EMBO journal2013
The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.
Article in The EMBO journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Microfluidic low-input profiling reveals lncRNA roles in disease.bioRxiv : the preprint server for biology · 2026Article
- Development and modeling of cardiac autonomic innervation.Nature cardiovascular research · 2025Review
- Systematic analysis identifies a connection between spatial and genomic variations of chromatin states.Cell systems · 2024Article
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- Canalizing cell fate by transcriptional repression.Molecular systems biology · 2024Review
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- The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.Cell and tissue research · 2021Review
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
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- A human cell atlas of fetal gene expression.Science (New York, N.Y.) · 2020Article
- The diversity of neuronal phenotypes in rodent and human autonomic ganglia.Cell and tissue research · 2020Review
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- Comparative Analysis of Dorsal Root, Nodose and Sympathetic Ganglia for the Development of New Analgesics.Frontiers in neuroscience · 2020Article
- Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development.Scientific reports · 2019Article
- Cell-Type Identification in the Autonomic Nervous System.Neuroscience bulletin · 2019Review
- Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies.Neural development · 2018Review
- Epigenetic maintenance of topological domains in the highly rearranged gibbon genome.Genome research · 2018Article
- Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.Cell death & disease · 2018Article
- Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.Science (New York, N.Y.) · 2017Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic nervous system relies on distinct populations of neurons that use noradrenaline or acetylcholine as neurotransmitter. We show that fating of the sympathetic lineage at early stages results in hybrid precursors from which, genetic cell-lineage tracing reveals, all types progressively emerge by principal mechanisms of maintenance, repression and induction of phenotypes. The homeobox transcription factor HMX1 represses Tlx3 and Ret, induces TrkA and maintains tyrosine hydroxylase (Th) expression in precursors, thus driving segregation of the noradrenergic sympathetic fate. Cholinergic sympathetic neurons develop through cross-regulatory interactions between TRKC and RET in precursors, which lead to Hmx1 repression and sustained Tlx3 expression, thereby resulting in failure of TrkA induction and loss of maintenance of Th expression. Our results provide direct evidence for a model in which diversification of noradrenergic and cholinergic sympathetic neurons is based on a principle of cross-repressive functions in which the specific cell fates are directed by an active suppression of the expression of transcription factors and receptors that direct the alternative fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.