Evidence map›Paper›PMID 23591273›Full record

Trial reportThe Journal of allergy and clinical immunology2013

The association of health literacy with adherence and outcomes in moderate-severe asthma.

Andrea J Apter, Fei Wan, Susan Reisine, Bruce Bender, Cynthia Rand, Daniel K Bogen, Ian M Bennett, Tyra Bryant-Stephens, Jason Roy, Rodalyn Gonzalez and 3 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01972308 nacompletednot on this map

A Patient Advocate to Improve Real-world Asthma Management for Inner City Adults

TypeinterventionalSponsorUniversity of PennsylvaniaRan2013 to 2022Enrolled312ConditionsAsthma, CommunicationArmsPatient Advocate, Usual Care
NCT07224061 narecruitingnot on this mapstarted 2026, after this paper: background citation

Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination in Clinics and Schools (PRAGMATIC-S)

TypeinterventionalSponsorMontefiore Medical CenterRan2026 to 2033Enrolled420ConditionsAsthma in ChildrenArmsPRAGMATIC-S
3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Factors Affecting Adherence in Allergic Disorders and Strategies for Improvement.The journal of allergy and clinical immunology. In practice · 2024
    Review
  8. Article
  9. Health literacy and asthma: An update.The Journal of allergy and clinical immunology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Low parental numeracy and severe asthma exacerbations in a prospective study of Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrea J ApterSection of Allergy and Immunology, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pa 19104, USA. apter@mail.med.upenn.edu
Fei Wan
Susan Reisine
Bruce Bender
Cynthia Rand
Daniel K Bogen
Ian M Bennett
Tyra Bryant-Stephens
Jason Roy
Rodalyn Gonzalez
Chantel Priolo
Thomas Ten Have
Knashawn H Morales

Funding

Individualized Interventions to Improve Asthma AdherenceR01HL073932 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI APTER, ANDREA J. · 2005 to 2009
$3.6M
A Patient Advocate and Literacy-Based Treatment of AsthmaRC1HL099612 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI APTER, ANDREA J. · 2009 to 2010
$1.0M
Literacy and improving patient-clinician encounters for AsthmaK02HL088469 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI APTER, ANDREA J. · 2007 to 2011
$526k
NHLBI NIH HHS HL070392NHLBI NIH HHS HL088469NHLBI NIH HHS K02 HL088469NHLBI NIH HHS R01 HL073932NHLBI NIH HHS RC1 HL099612NHLBI NIH HHS RC1HL099612
6 · The paper itself

Abstract

backgroundLow health literacy is associated with poor outcomes in asthma and other diseases, but the mechanisms governing this relationship are not well defined.

objectiveWe sought to assess whether literacy is related to subsequent asthma self-management, measured as adherence to inhaled steroids, and asthma outcomes.

methodsIn a prospective longitudinal cohort study, numeric (Asthma Numeracy Questionnaire) and print literacy (Short Test of Functional Health Literacy in Adults) were assessed at baseline in adults with moderate or severe asthma for their impact on subsequent electronically monitored adherence and asthma outcomes (asthma control, asthma-related quality of life, and FEV1) over 26 weeks, using mixed-effects linear regression models.

resultsA total of 284 adults participated: age, 48 ± 14 years, 71% females, 70% African American, 6% Latino, mean FEV1 66% ± 19%, 86 (30%) with hospitalizations, and 148 (52%) with emergency department visits for asthma in the prior year. Mean Asthma Numeracy Questionnaire score was 2.3 ± 1.2 (range, 0-4); mean Short Test of Functional Health Literacy in Adults score was 31 ± 8 (range, 0-36). In unadjusted analyses, numeric and print literacy were associated with better adherence (P = .01 and P = .08, respectively), asthma control (P = .005 and P < .001, respectively), and quality of life (P < .001 and P < .001, respectively). After controlling for age, sex, and race/ethnicity, the associations diminished and only quality of life (numeric P = .03, print P = .006) and asthma control (print P = .005) remained significantly associated with literacy. Race/ethnicity, income, and educational attainment were correlated (P < .001).

conclusionWhile the relationship between literacy and health is complex, interventions that account for and address the literacy needs of patients may improve asthma outcomes.

Indexed as

Health LiteracyAdministration, InhalationAdrenal Cortex HormonesAdultAsthmaBlack or African AmericanCohort StudiesFemaleHispanic or LatinoHospitalizationHumansMaleMedication AdherenceMiddle AgedProspective StudiesQuality of LifeAdrenal Cortex HormonesadherenceadultsAEANQAQOLasthmaasthma controlAsthma educationAsthma Numeracy Questionnaireasthma-related quality of lifeAsthma-related quality of lifeEDEmergency departmentHealth literacyICSInhaled corticosteroidinhaled corticosteroidsinner-city asthmanumeracyprint literacyProblem-solvingPSShort Test of Functional Health Literacy in AdultsS-TOFHLA

Identifiers

PMID23591273
PMCPMC3745278

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.