ArticleBritish journal of cancer2013
Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer.Journal of experimental & clinical cancer research : CR · 2025Article
- Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.Cancer science · 2024Article
- SPINOPHILIN: A multiplayer tumor suppressor.Genes & diseases · 2023Review
- Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle.Cancers · 2021Review
- Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.Theranostics · 2021Article
- Modulated Start-Up Mode of Cancer Cell Migration Through Spinophilin-Tubular Networks.Frontiers in cell and developmental biology · 2021Article
- Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.Oncotarget · 2018Article
- Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer.Oncotarget · 2017Article
- Article
- Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors.Oncogene · 2016Article
- Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma.British journal of cancer · 2015Article
- Low spinophilin expression enhances aggressive biological behavior of breast cancer.Oncotarget · 2015Article
- Significance of MMP11 and P14(ARF) expressions in clinical outcomes of patients with laryngeal cancer.International journal of clinical and experimental medicine · 2015Article
- Multi-omics in prognosis of hepatocellular carcinoma.Annals of translational medicine · 2015Article
- Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer.Oncotarget · 2014Article
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13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinophilin, a multifunctional intracellular scaffold protein, is reduced in certain types of cancer and is regarded as a novel putative tumour suppressor protein. However, the role of spinophilin in hepatocellular carcinoma (HCC) has never been explored before.
methodsIn this study, we determined for the first time the expression pattern of spinophilin in human HCC by immunohistochemistry and quantitative reverse transcriptase-PCR analysis. In addition, we performed immunohistochemical analysis of p53, p14(ARF) and the proliferation marker Ki-67. Kaplan-Meier curves and multivariate Cox proportional models were used to study the impact on clinical outcome. Small interfering RNA (siRNA) was used to silence spinophilin and to explore the effects of reduced spinophilin expression on cellular growth.
resultsIn our study, complete loss of spinophilin immunoreactivity was found in 44 of 104 HCCs (42.3%) and reduced levels were found in an additional 37 (35.6%) cases. After adjusting for other prognostic factors, multivariate Cox regression analysis identified low expression of spinophilin as an independent prognostic factor with respect to disease-free (hazard ratio (HR)=1.8; 95% confidence interval (CI)=1.04-3.40; P=0.043) and cancer-specific survival (HR=2.0; CI=1.1-3.8; P=0.025). Reduced spinophilin expression significantly correlated with higher Ki-67 index in HCC (P=0.014). Reducing spinophilin levels by siRNA induced a higher cellular growth rate and increased cyclin D2 expression in tumour cells (P<0.05).
conclusionThis is the first study of the expression pattern and distribution of spinophilin in HCC. According to our data, the loss of spinophilin is associated with higher proliferation and might be useful as a prognostic marker in patients with HCC.
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