ArticleNeuroImage2013
Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- MatchingFrontiers in neuroanatomy · 2019Pooled it
- Iron dyshomeostasis and its neurobiological mechanisms in psychiatric disorders.Molecular psychiatry · 2026Review
- Review
- Regulation of brain iron homeostasis and its influence on cognitive function.European radiology · 2026Article
- Hippocampal Subfield Susceptibility Alterations in Mild Cognitive Impairment Revealed by 7T MRI.AJNR. American journal of neuroradiology · 2026Article
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- Quantitative susceptibility mapping demonstrates ageing-related long-term structural brain changes in adult rats after mild ischaemic stroke.Brain communications · 2026Article
- Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center.Annals of clinical and translational neurology · 2025Article
- Machine learning diagnostic model for amyotrophic lateral sclerosis analysis using MRI-derived features.Neuroradiology · 2025Article
- Quantitative susceptibility mapping shows alterations of brain iron content in children with autism spectrum disorder: a whole-brain analysis.BMC psychiatry · 2025Article
- Comparing repeatability metrics for quantitative susceptibility mapping in the head and neck.Magma (New York, N.Y.) · 2025Article
- Quantitative susceptibility mapping study of deep gray matter iron content in glioma patients.Quantitative imaging in medicine and surgery · 2025Article
- Regional high iron deposition on brain quantitative susceptibility mapping correlates with cognitive decline in chronic kidney disease patients.Brain imaging and behavior · 2025Article
- Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic responseFrontiers in oncology · 2025Article
- Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis.Brain and behavior · 2025Article
- Article
- Quantitative susceptibility mapping in the brain reflects spatial expression of genes involved in iron homeostasis and myelination.Human brain mapping · 2024Article
- Comparison of three magnetic resonance imaging measures of brain iron in healthy and cocaine use disorder participants.NMR in biomedicine · 2024Article
- Evaluation of multi-channel phase reconstruction methods for quantitative susceptibility mapping on postmortem human brain.Journal of magnetic resonance open · 2023Article
- The 3D Structural Architecture of the Human Hand Area Is Nontopographic.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Measuring iron content in the brain has important implications for a number of neurodegenerative diseases. Quantitative susceptibility mapping (QSM), derived from magnetic resonance images, has been used to measure total iron content in vivo and in post mortem brain. In this paper, we show how magnetic susceptibility from QSM correlates with total iron content measured by X-ray fluorescence (XRF) imaging and by inductively coupled plasma mass spectrometry (ICPMS). The relationship between susceptibility and ferritin iron was estimated at 1.10±0.08 ppb susceptibility per μg iron/g wet tissue, similar to that of iron in fixed (frozen/thawed) cadaveric brain and previously published data from unfixed brains. We conclude that magnetic susceptibility can provide a direct and reliable quantitative measurement of iron content and that it can be used clinically at least in regions with high iron content.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.