ArticlePlant physiology2013
Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The Main Functions of Plastids.Methods in molecular biology (Clifton, N.J.) · 2024Review
- OPA1 drives macrophage metabolism and functional commitment via p65 signaling.Cell death and differentiation · 2023Article
- Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NADIUBMB life · 2022Review
- Article
- Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.EMBO molecular medicine · 2020Article
- Characterization of In Vivo Function(s) of Members of the Plant Mitochondrial Carrier Family.Biomolecules · 2020Review
- Peroxisomal Cofactor Transport.Biomolecules · 2020Review
- Metabolic Roles of Plant Mitochondrial Carriers.Biomolecules · 2020Review
- Plant peroxisomal solute transporter proteins.Journal of integrative plant biology · 2019Review
- Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.Antioxidants & redox signaling · 2017Article
- Dissecting the Metabolic Role of Mitochondria during Developmental Leaf Senescence.Plant physiology · 2016Article
- The Peroxisomal NAD Carrier from Arabidopsis Imports NAD in Exchange with AMP.Plant physiology · 2016Article
- Mutation of the mitochondrial carrier SLC25A42 causes a novel form of mitochondrial myopathy in humans.Human genetics · 2016Article
- The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica.Journal of bacteriology · 2015Article
- Power(2): the power of yeast genetics applied to the powerhouse of the cell.Trends in endocrinology and metabolism: TEM · 2015Review
- Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.Diabetologia · 2014Article
- Transport pathways--proton motive force interrelationship in durum wheat mitochondria.International journal of molecular sciences · 2014Review
- Divisions of labor in the thiamin biosynthetic pathway among organs of maize.Frontiers in plant science · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants make coenzyme A (CoA) in the cytoplasm but use it for reactions in mitochondria, chloroplasts, and peroxisomes, implying that these organelles have CoA transporters. A plant peroxisomal CoA transporter is already known, but plant mitochondrial or chloroplastic CoA transporters are not. Mitochondrial CoA transporters belonging to the mitochondrial carrier family, however, have been identified in yeast (Saccharomyces cerevisiae; Leu-5p) and mammals (SLC25A42). Comparative genomic analysis indicated that angiosperms have two distinct homologs of these mitochondrial CoA transporters, whereas nonflowering plants have only one. The homologs from maize (Zea mays; GRMZM2G161299 and GRMZM2G420119) and Arabidopsis (Arabidopsis thaliana; At1g14560 and At4g26180) all complemented the growth defect of the yeast leu5Δ mitochondrial CoA carrier mutant and substantially restored its mitochondrial CoA level, confirming that these proteins have CoA transport activity. Dual-import assays with purified pea (Pisum sativum) mitochondria and chloroplasts, and subcellular localization of green fluorescent protein fusions in transiently transformed tobacco (Nicotiana tabacum) Bright Yellow-2 cells, showed that the maize and Arabidopsis proteins are targeted to mitochondria. Consistent with the ubiquitous importance of CoA, the maize and Arabidopsis mitochondrial CoA transporter genes are expressed at similar levels throughout the plant. These data show that representatives of both monocotyledons and eudicotyledons have twin, mitochondrially located mitochondrial carrier family carriers for CoA. The highly conserved nature of these carriers makes possible their reliable annotation in other angiosperm genomes.
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