Trial reportPsychological medicine2014
Modelling the interplay between childhood and adult adversity in pathways to psychosis: initial evidence from the AESOP study.
Trial report in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
- Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.Schizophrenia bulletin · 2026Article
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- Article
- Association of childhood maltreatment and adverse lifetime experiences with post-injury psychopathology: evidence from the China Severe Trauma Cohort.BMC medicine · 2025Article
- Momentary Self-esteem as a Process Underlying the Association Between Childhood Trauma and Psychosis: Experience Sampling Study.JMIR mental health · 2023Article
- [Public mental health from an international perspective: from "shifting the curve" to inclusion of vulnerable populations].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Article
- A Compassion-Focused Ecological Momentary Intervention for Enhancing Resilience in Help-Seeking Youth: Uncontrolled Pilot Study.JMIR mental health · 2021Article
- Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study.Epidemiology and psychiatric sciences · 2021Article
- Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia.JAMA psychiatry · 2020Observational
- The effects of psychosocial stress on dopaminergic function and the acute stress response.eLife · 2019Article
- Childhood abuse and psychotic experiences - evidence for mediation by adulthood adverse life events.Epidemiology and psychiatric sciences · 2019Article
- Cumulative Effects of Neighborhood Social Adversity and Personal Crime Victimization on Adolescent Psychotic Experiences.Schizophrenia bulletin · 2018Article
- The interplay of psychosis and victimisation across the life course: a prospective study in the general population.Social psychiatry and psychiatric epidemiology · 2017Article
- Exploring the Intersections of Trauma, Structural Adversity, and Psychosis among a Primarily African-American Sample: A Mixed-Methods Analysis.Frontiers in psychiatry · 2017Article
- Adversity in childhood linked to elevated striatal dopamine function in adulthood.Schizophrenia research · 2016Article
- Psychological processes underlying the association between childhood trauma and psychosis in daily life: an experience sampling study.Psychological medicine · 2016Article
- Psychosis as a transdiagnostic and extended phenotype in the general population.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Childhood adversities and psychosis: evidence, challenges, implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Neuroscience and the future for mental health?Epidemiology and psychiatric sciences · 2016Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundThere is evidence that a range of socio-environmental exposures is associated with an increased risk of psychosis. However, despite the fact that such factors probably combine in complex ways to increase risk, the majority of studies have tended to consider each exposure separately. In light of this, we sought to extend previous analyses of data from the AESOP (Aetiology and Ethnicity in Schizophrenia and Other Psychoses) study on childhood and adult markers of disadvantage to examine how they combine to increase risk of psychosis, testing both mediation (path) models and synergistic effects.
methodAll patients with a first episode of psychosis who made contact with psychiatric services in defined catchment areas in London and Nottingham, UK (n = 390) and a series of community controls (n = 391) were included in the AESOP study. Data relating to clinical and social variables, including parental separation and loss, education and adult disadvantage, were collected from cases and controls.
resultsThere was evidence that the effect of separation from, but not death of, a parent in childhood on risk of psychosis was partially mediated through subsequent poor educational attainment (no qualifications), adult social disadvantage and, to a lesser degree, low self-esteem. In addition, there was strong evidence that separation from, but not death of, a parent combined synergistically with subsequent disadvantage to increase risk. These effects held for all ethnic groups in the sample.
conclusionsExposure to childhood and adult disadvantage may combine in complex ways to push some individuals along a predominantly sociodevelopmental pathway to psychosis.
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