ArticleCell communication and signaling : CCS2013
The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction.
Article in Cell communication and signaling : CCS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- The Genetics of Diabetes: What We Can Learn fromInternational journal of molecular sciences · 2021Review
- Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size.G3 (Bethesda, Md.) · 2021Article
- Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.Genetics · 2021Article
- Article
- Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.Frontiers in endocrinology · 2021Article
- Tissue-Specific Upregulation of Drosophila Insulin Receptor (InR) Mitigates Poly(Q)-Mediated Neurotoxicity by Restoration of Cellular Transcription Machinery.Molecular neurobiology · 2019Article
- Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation.Stem cell reports · 2018Article
- Review
- Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome.Endocrinology · 2016Article
- Article
- LNK (SH2B3): paradoxical effects in ovarian cancer.Oncogene · 2015Article
- SH2B1 regulation of energy balance, body weight, and glucose metabolism.World journal of diabetes · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin/insulin-like growth factor signalling (IIS) has been described as one of the major pathways involved in growth control and homeostasis in multicellular organisms. Whereas its core components are well established, less is known about the molecular functions of IIS regulators. The adaptor molecule Lnk/SH2B has been implicated in IIS but the mechanism by which it promotes IIS activity has remained enigmatic.
resultsIn this study, we analyse genetic and physical interactions among InR, Chico and Lnk in Drosophila tissues. FRET analysis reveals in vivo binding between all three molecules. Genetically, Lnk acts upstream of Chico. We demonstrate that Chico's plasma membrane localisation is ensured by both its PH domain and by the interaction with Lnk. Furthermore, Lnk is able to recruit an intracellular InR fragment to the membrane.
conclusionsThus, by acting as a scaffolding molecule that ensures InR and Chico enrichment at the membrane, Lnk provides a fail-safe mechanism for IIS activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.