ArticleMicrobial cell factories2013
Diversity of marine bacteria producing beta-glucosidase inhibitors.
Article in Microbial cell factories, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- In silico prediction of potential indigenous microbial biomarkers in Penaeus vannamei identified through meta-analysis and genome-scale metabolic modelling.Environmental microbiome · 2023Article
- Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Discovery of α-Glucosidase Inhibitors from Marine Microorganisms: Optimization of Culture Conditions and Medium Composition.Molecular biotechnology · 2021Article
- Glucosidase Inhibitors Screening in Microalgae and Cyanobacteria Isolated from the Amazon and Proteomic Analysis of Inhibitor ProducingMicroorganisms · 2021Article
- Marine macroalga-associated heterotroph Bacillus velezensis as prospective therapeutic agent.Archives of microbiology · 2021Article
- Metabolomic Profile of Weaned Pigs Challenged withMetabolites · 2021Article
- Application 2D Descriptors and Artificial Neural Networks for Beta-Glucosidase Inhibitors Screening.Molecules (Basel, Switzerland) · 2020Article
- Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters.Scientific reports · 2020Article
- Role of symbiosis in the discovery of novel antibiotics.The Journal of antibiotics · 2020Review
- Some Functional Properties ofFrontiers in microbiology · 2019Article
- Potential Anticoagulant Activity of Trypsin Inhibitor Purified from an Isolated Marine Bacterium Oceanimonas Sp. BPMS22 and its Kinetics.Marine biotechnology (New York, N.Y.) · 2018Article
- Identification of Cultivable Bacteria from Tropical Marine Sponges and Their Biotechnological Potentials.Tropical life sciences research · 2018Article
- Analysis of Bacterial Diversity in Different Heavy Oil Wells of a Reservoir in South Oman with Alkaline pH.Scientifica · 2018Article
- Isolation, selection, and biological characterization research of highly effective electricigens from MFCs for phenol degradation.Folia microbiologica · 2018Article
- Marine Peptides as Potential Agents for the Management of Type 2 Diabetes Mellitus-A Prospect.Marine drugs · 2017Review
- Marine Organisms with Anti-Diabetes Properties.Marine drugs · 2016Review
- Biodegradation of fluoranthene by a newly isolated strain of Bacillus stratosphericus from Mediterranean seawater of the Sfax fishing harbour, Tunisia.Environmental science and pollution research international · 2016Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta-glucosidase inhibitors are being extensively studied for use as anti-diabetics, anti-obesity and anti-tumour compounds. So far, these compounds have been reported in large numbers from plants, mushrooms, algae and fungi. There are very few reports of such inhibitors from bacteria in the open literature, particularly marine bacteria; although the best known inhibitor deoxynojirimycin was isolated from bacilli and actinomycete. Through this study, we tried to discover the diversity of microbial associates of marine sponge and sediment producing β-glucosidase inhibitors.
resultsWe found 41 (22.7%) out of 181 bacteria, produced such inhibitors. The inhibitors are abundant in bacterial associates of marine sponge Aka coralliphaga. When these bacteria were phylogenetically analyzed, it was found that marine bacteria producing glucosidase inhibitors belong to the phylum Firmicutes (23), Actinobacteria (9), Proteobacteria (7) and Bacteroidetes (1).
conclusionA significant number of marine bacteria belonging to a wide range of bacterial taxa were found to produce β-glucosidase inhibitors. These compounds are abundantly present in bacteria of the phylum Firmicutes followed by the phylum Actinobacteria. The results nurture a hope of finding new compounds, which can inhibit glucosidases, in the bacterial domain of marine organisms. Thus, marine microbial cells can be utilized as producers of pharmacologically essential enzyme inhibitors.
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