ArticleAmerican journal of respiratory and critical care medicine2013
Perinatal tumor necrosis factor-α production, influenced by maternal pregnancy weight gain, predicts childhood asthma.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma.Pediatrics · 2014Pooled it
- Associations of α- and γ-tocopherol during early life with lung function in childhood.The Journal of allergy and clinical immunology · 2020Trial
- Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Excessive gestational weight gain and risk of asthma, rhinitis and allergic sensitization: Results from a Portuguese birth cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Network analysis reveals protein modules associated with childhood respiratory diseases.The Journal of allergy and clinical immunology · 2025Article
- Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.Nutrients · 2024Article
- IgE versus IgG and IgA: Differential roles of allergen-specific antibodies in sensitization, tolerization, and treatment of allergies.Immunological reviews · 2024Review
- Causality between various cytokines and asthma: a bidirectional two-sample Mendelian randomization analysis.Frontiers in medicine · 2024Article
- Cohort Study of Maternal Gestational Weight Gain, Gestational Diabetes, and Childhood Asthma.Nutrients · 2022Article
- Maternal BMI and allergy in children until 3 years of age (JECS).The journal of allergy and clinical immunology. Global · 2022Article
- Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.Brain, behavior, and immunity · 2022Article
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles.Frontiers in immunology · 2022Review
- Examining the role of pre-pregnancy weight and gestational weight gain in allergic disease development among offspring: A population-based cohort study in Ontario, Canada.Paediatric and perinatal epidemiology · 2022Article
- Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma.Immunity, inflammation and disease · 2021Article
- Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada.BMJ paediatrics open · 2021Article
- Leptin in Cord Blood Associates with Asthma Risk at Age 3 in the Offspring of Women with Gestational Obesity.Annals of the American Thoracic Society · 2020Article
- Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams.Clinical and translational science · 2020Article
- Association of Maternal Prepregnancy Weight and Gestational Weight Gain With Children's Allergic Diseases.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleInnate immune responses marked by increases in tumor necrosis factor (TNF)-α have been associated with asthma but whether such alterations are evident before symptoms is not yet clear.
objectivesTo determine if prevalence of childhood asthma or asthma-related traits is predicted by perinatal innate immune status and if maternal factors related to pregnancy influence asthma prevalence and innate immune status.
methodsIn the Tucson Infant Immune Study (a nonselected birth cohort), presence of eczema and wheezing in the child's first year and physician-diagnosed asthma through age 9 and asthma in the parents was obtained from parent-completed questionnaires. TNF-α, IL-6, IL-10, and IL-12 were measured in supernatants of LPS-stimulated peripheral blood mononuclear cells at birth and 3 months as was TNF-α in plasma. TNF-α single nucleotide polymorphisms were genotyped by Sequenom. Percent predicted FEV1/FVC was measured at age 9. Maternal weight gain during pregnancy and prepregnancy weight were ascertained from medical records. MEASUREMENTS AND MAIN
resultsInfants with persistently elevated LPS-induced TNF-α at birth and 3 months were at increased risk for childhood asthma (odds ratio [OR], 4.1; confidence interval [CI], 1.9-8.8; n = 233; P = 0.0003) and had decreased FEV1/FVC ratios at age 9. Children with mothers in the top tertile for pregnancy weight gain had increased risk for asthma (OR, 3.4; CI, 1.7-6.9; n = 225; P = 0.001) and persistently elevated TNF-α in early life (OR, 2.9; CI, 1.4-8.2; n = 195; P = 0.013). These relations were independent of maternal asthma and rhinitis.
conclusionsPersistently elevated LPS-induced TNF-α production early in life acts as a predictive biomarker for childhood asthma, and excess pregnancy weight gain in the mother seems to contribute to both.
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Registered trials
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