ArticleAmerican journal of respiratory and critical care medicine2013
Cytokine complex-expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Chronic Lung Allograft Dysfunction: Clinical Manifestations and Immunologic Mechanisms.Transplantation · 2025Review
- NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction.JCI insight · 2025Article
- CD94The European respiratory journal · 2024Article
- 17β-estradiol and methylprednisolone association as a therapeutic option to modulate lung inflammation in brain-dead female rats.Frontiers in immunology · 2024Article
- Allorecognition Unveiled: Integrating Recent Breakthroughs Into the Current Paradigm.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants.Frontiers in immunology · 2024Article
- CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.JCI insight · 2023Article
- Protective and pathogenic functions of innate lymphoid cells in transplantation.Clinical and experimental immunology · 2023Review
- Insight on immune cells in rejection and infection postlung transplant.Immunity, inflammation and disease · 2023Review
- Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice.Nature communications · 2023Article
- Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Lymphocytic Airway Inflammation in Lung Allografts.Frontiers in immunology · 2022Review
- The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Recent advances in our understanding of the allograft response.Faculty reviews · 2021Review
- Bacterial products in donor airways prevent the induction of lung transplant tolerance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Investigation of hub genes and immune status in heart transplant rejection using endomyocardial biopsies.Journal of cellular and molecular medicine · 2021Article
- Sterile inflammation in thoracic transplantation.Cellular and molecular life sciences : CMLS · 2021Review
- Screening and identification of key regulatory connections and immune cell infiltration characteristics for lung transplant rejection using mucosal biopsies.International immunopharmacology · 2020Article
- The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse.Respiratory research · 2020Article
- Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation.Frontiers in immunology · 2020Article
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Abstract
rationaleNatural killer (NK) cells are innate lymphocytes that target virus-infected and tumor cells. Much less is known about their ability to limit adaptive immune responses.
objectivesThus, we investigated to what extent NK cells can influence mouse lung allograft rejection.
methodsFor this purpose, we employed an orthotopic lung transplantation model in mice. MEASUREMENTS AND MAIN
resultsWe demonstrate here that NK cells infiltrate mouse lung allografts before T cells and thereby diminished allograft inflammation, and that NK-cell deficiency enhanced allograft rejection. In contrast, expansion of recipient NK cells through IL-15/IL-15Rα complex treatment resulted in decreased T-cell infiltration and alloreactive T-cell priming as well as improved function of the allogeneic lung transplant. Only perforin-competent, but not perforin-deficient, NK cells were able to transfer these beneficial effects into transplanted NK cell-deficient IL-15Rα(-/-) mice. These NK cells killed allogeneic dendritic cells (DCs) in vitro and significantly decreased the number of allogeneic DCs in transplanted lungs in vivo. Furthermore, DC-depleted lung allografts presented decreased signs of rejection.
conclusionsThese results suggest that NK cells favor allograft acceptance by depleting donor-derived DCs, which otherwise would prime alloreactive T-cell responses. Thus, conditioning regimens that augment NK-cell reactivity should be clinically explored to prepare lung allograft recipients.
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