ArticleAmerican journal of respiratory and critical care medicine2013
Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00269256 (Stress, Environment, and Genetics in Urban Asthma), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress, Environment, and Genetics in Urban Asthma
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma.Pediatrics · 2014Pooled it
- Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- The Association Between Teenage Pregnancy and the Development of Asthma in Children Aged Zero to Five Years.Cureus · 2025Article
- Serial Diurnal Salivary Cortisol Profiles in 667 Pregnant Women-Association With Cardiometabolic Complications.The Journal of clinical endocrinology and metabolism · 2024Article
- Maternal stressful life events during pregnancy and childhood asthma and wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Associations between early-life exposure to PMEnvironmental epidemiology (Philadelphia, Pa.) · 2023Article
- Life Course of Asthma.Advances in experimental medicine and biology · 2023Article
- Prenatal lead exposure and childhood lung function: Influence of maternal cortisol and child sex.Environmental research · 2022Article
- Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity.International journal of obesity (2005) · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Perinatal origins of chronic lung disease: mechanisms-prevention-therapy-sphingolipid metabolism and the genetic and perinatal origins of childhood asthma.Molecular and cellular pediatrics · 2021Review
- Maternal Prenatal Hair Cortisol Is Associated with Child Wheeze among Mothers and Infants with Tobacco Smoke Exposure and Who Face High Socioeconomic Adversity.International journal of environmental research and public health · 2021Article
- Integrated and diurnal indices of maternal pregnancy cortisol in relation to sex-specific parasympathetic responsivity to stress in infants.Developmental psychobiology · 2021Article
- Asthma epidemiology and risk factors.Seminars in immunopathology · 2020Review
- Maternal childhood and lifetime traumatic life events and infant bronchiolitis.Paediatric and perinatal epidemiology · 2019Article
- Prenatal cortisol modifies the association between maternal trauma history and child cognitive development in a sex-specific manner in an urban pregnancy cohort.Stress (Amsterdam, Netherlands) · 2019Article
- Maternal Lifetime Trauma and Birthweight: Effect Modification by In Utero Cortisol and Child Sex.The Journal of pediatrics · 2018Article
- Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length.Psychoneuroendocrinology · 2018Article
- Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex.The Journal of allergy and clinical immunology · 2018Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleExploring prenatal factors influencing childhood wheeze may inform programming mechanisms.
objectivesWe examined associations among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years (n = 261).
methodsSalivary cortisol was collected five times per day over 3 days at 29.0 ± 4.9 weeks gestation. Mothers were categorized as obese (body mass index ≥ 30 kg/m(2)) versus nonobese (body mass index < 30 kg/m(2)). Using logistic regression, we examined the influence of log-transformed cortisol metrics (level at each time point, morning rise, diurnal and afternoon slopes) and obesity on wheeze adjusting for covariates. Linear mixed models were implemented to examine associations between cortisol trajectories and wheezing. Interactions between maternal cortisol and obesity were considered. MEASUREMENTS AND MAIN
resultsMothers were primarily minority (56.5% Hispanic, 24.1% African American), 61% had less than or equal to 12 years of education, 34% were obese, and 8.4% of children had repeated wheeze. An interquartile range increase in mean log cortisol at bedtime (odds ratio, 2.2; 95% confidence interval, 1.09-4.09) and maternal obesity (odds ratio, 3.43; 95% confidence interval, 1.26-9.35) were independently associated with wheeze. Linear mixed models revealed an association between a flatter afternoon slope (slower decline in log cortisol per hour) and repeated wheeze in children of obese mothers (children with [-0.017 change] and without [-0.061 change] wheeze [P = 0.009 for time × wheeze interaction]), but not in children of nonobese mothers (with [-0.050 change] and without [-0.061 change] wheeze [P = 0.51]).
conclusionsMaternal prenatal cortisol disruption and obesity were independently associated with children's wheeze. Obese women with adverse cortisol profiles were most likely to have children with repeated wheeze.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.