Trial reportJournal of the American Geriatrics Society2013
White matter hyperintensities, exercise, and improvement in gait speed: does type of gait rehabilitation matter?
Trial report in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Callosal hyperintensities and gait speed gain from two types of mobility interventions in older adults.Archives of physical medicine and rehabilitation · 2015Trial
- Real-world walking patterns are associated with regional brain atrophy and white matter lesions in middle-aged and older people: a Watch Walk-UK Biobank study.GeroScience · 2026Article
- The Role of Brain Structure in Explaining Physical Functioning in Male Veterans With Impaired Kidney Function.Journal of the American Geriatrics Society · 2026Article
- Gait variability as a marker of white matter integrity in individuals with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Observational
- Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.Neurobiology of aging · 2023Observational
- Making More of IT: Enabling Intensive Motor Cognitive Rehabilitation Exercises in Geriatrics Using Information Technology Solutions.BioMed research international · 2018Review
- Contributors to Poor Mobility in Older Adults: Integrating White Matter Hyperintensities and Conditions Affecting Other Systems.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- An exploratory intervention study suggests clinical benefits of training in chronic stroke to be paralleled by changes in brain activity using repeated fMRI.Clinical interventions in aging · 2016Article
- Effects of white matter lesions on trunk stability during dual-task walking among older adults with mild cognitive impairment.Age (Dordrecht, Netherlands) · 2015Article
- Successful aging: Advancing the science of physical independence in older adults.Ageing research reviews · 2015Review
- Neuroimaging of mobility in aging: a targeted review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Review
- Aging, motor skill, and the energy cost of walking: implications for the prevention and treatment of mobility decline in older persons.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Review
- Association between cerebellar gray matter volumes, gait speed, and information-processing ability in older adults enrolled in the Health ABC study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Activity engagement and physical function in old age sample.Archives of gerontology and geriatricsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine whether white matter hyperintensities (WMHs) on brain magnetic resonance imaging (MRI) in tracts in older adults with mobility impairment are linked to outcomes of gait rehabilitation interventions.
designTwelve-week randomized controlled single-blind trial.
settingUniversity-based mobility research laboratory.
participantsAmbulatory adults aged 65 and older with mobility impairment.
interventionA conventional gait intervention focusing on walking, endurance, balance, and strength (WEBS, n = 21) and a task-oriented intervention focused on timing and coordination of gait (TC, n = 23). MEASUREMENTS: Self-paced gait speed was measured over an instrumented walkway before and after the intervention, and WMH and brain volumes were quantified on preintervention brain MRI using an automated segmentation process. A white matter tract atlas was overlaid on the segmented images to measure tract WMH volumes, and WMH volumes were normalized to total brain volume. Aggregate WMH volumes in all white matter tracts and individual WMH volumes in specific longitudinal tracts (superior longitudinal fasciculus, inferior longitudinal fasciculus, and fronto-occipital fasciculus) and the cingulum were measured.
resultsGait speed gains in the TC group were of the same magnitude, independent of WMH volume measures in all except the cingulum, but in the WEBS group, gain in gait speed was smaller with greater overall tract WMH volumes (P < .001) and with greater WMH volume in the three longitudinal tracts (P < .001 to .02).
conclusionGains in gait speed with two types of gait rehabilitation are associated with individual differences in WMHs. Task-oriented therapy that targets timing and coordination of gait may particularly benefit older adults with WMHs in brain tracts that influence gait and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.