Evidence map›Paper›PMID 23590123›Full record

ArticleJournal of the American Chemical Society2013

Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.

Jae Hyun Jeong, John J Schmidt, Richie E Kohman, Andrew T Zill, Ross J DeVolder, Cartney E Smith, Mei-Hsiu Lai, Artem Shkumatov, Tor W Jensen, Lawrence G Schook and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 82 citations in OpenAlex.

  1. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  2. Cell-drug conjugates.Nature biomedical engineering · 2024
    Review
  3. Article
  4. Article
  5. Cell Surface Engineering Tools for Programming Living Assemblies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Polyvalent Display of Biomolecules on Live Cells.Angewandte Chemie (International ed. in English) · 2018
    Article
  16. Review
  17. Article
  18. Engineering Polymersomes for Diagnostics and Therapy.Advanced healthcare materials · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jae Hyun JeongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
John J Schmidt
Richie E Kohman
Andrew T Zill
Ross J DeVolder
Cartney E Smith
Mei-Hsiu Lai
Artem Shkumatov
Tor W Jensen
Lawrence G Schook
Steven C Zimmerman
Hyunjoon Kong
University of Illinois Urbana-Champaign · US

Funding

Nanocells for vascular normalization therapiesR01HL109192 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2011 to 2015
$1.9M
Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI MR25CA154015 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID, NARDULLI, ANN · 2010 to 2014
$1.5M
Nano-sized Cell Guidance System for Ischemic Tissue RepairR21HL097314 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2009 to 2010
$410k
NCI NIH HHS 1R25CA154015ANCI NIH HHS R25 CA154015NHLBI NIH HHS 1R01 HL109192NHLBI NIH HHS 1R21 HL097314NHLBI NIH HHS R01 HL109192NHLBI NIH HHS R21 HL097314
6 · The paper itself

Abstract

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

Indexed as

Amino Acid SequenceAnimalsCell AdhesionEndothelium, VascularEndovascular ProceduresGlycerolHumansInjectionsLeukocytesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPeptidesPolymersGlycerolPeptidespolyglycerolPolymers

Identifiers

PMID23590123
PMCPMC3688670
OpenAlexW2037462412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.