ArticleProceedings of the National Academy of Sciences of the United States of America2013
Dosage compensation and inverse effects in triple X metafemales of Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Transcription initiation drives dosage compensation establishment and maintenance in maleScience advances · 2026Article
- Gene Dosage Sensitivity and Human Genetic Diseases.Journal of inherited metabolic disease · 2025Review
- Global modulation of gene expression and transcriptome size in aneuploid combinations of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas.Scientific reports · 2025Article
- Exploring genome-transcriptome correlations in cancer.Biochemical Society transactions · 2025Review
- Dynamics and regulatory roles of RNA meLife · 2025Article
- Drift drives the evolution of chromosome number II: The impact of range size on genome evolution in Carnivora.The Journal of heredity · 2024Article
- Inverse and ProportionalGenes · 2024Article
- Article
- Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems-level property in cancer.Cancer medicine · 2023Review
- Aneuploidy effects on human gene expression across three cell types.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in MetafemaleInternational journal of molecular sciences · 2023Article
- Genome-Wide Effects on Gene Expression Between Parental and Filial Generations of Trisomy 11 and 12 of Rice.Rice (New York, N.Y.) · 2023Article
- Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility.Frontiers in molecular biosciences · 2023Article
- Dosage Compensation inInternational journal of molecular sciences · 2022Review
- Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania.PLoS pathogens · 2022Article
- The multiple fates of gene duplications: Deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation.The Plant cell · 2022Article
- Dosage-sensitive miRNAs trigger modulation of gene expression during genomic imbalance in maize.Nature communications · 2022Article
- Dissecting cricket genomes for the advancement of entomology and entomophagy.Biophysical reviews · 2022Review
- Article
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6 authors.
Funding
Abstract
Dosage compensation, the equalized X chromosome gene expression between males and females in Drosophila, has also been found in triple X metafemales. Inverse dosage effects, produced by genomic imbalance, are believed to account for this modulated expression, but they have not been studied on a global level. Here, we show a global expression comparison of metafemales (XXX; AA) with normal females (XX; AA) with high-throughput RNA-sequencing. We found that the majority of the X-linked genes in metafemales exhibit dosage compensation with an expression level similar to that of normal diploid females. In parallel, most of the autosomal genes were expressed at about two-thirds the level of normal females, the ratio of inverse dosage effects produced by the extra X chromosome. Both compensation and inverse effects were further confirmed by combination of X-linked and autosomally located miniwhite reporter genes in metafemales and relative quantitative PCR of selected genes. These data provide evidence for an inverse dosage component to X chromosome compensation.
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