ArticleOxidative medicine and cellular longevity2013
Therapeutic effect of MG132 on the aortic oxidative damage and inflammatory response in OVE26 type 1 diabetic mice.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients' Cells.Cells · 2022Article
- A Potential Target for Diabetic Vascular Damage: High Glucose-Induced Monocyte Extracellular Vesicles Impair Endothelial Cells by Delivering miR-142-5p.Frontiers in bioengineering and biotechnology · 2022Article
- Protective role of NRF2 in macrovascular complications of diabetes.Journal of cellular and molecular medicine · 2020Review
- The Protective Effects of Protease Inhibitor MG-132 on Sepsis-Induced Acute Lung Rats and Its Possible Mechanisms.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome.Nucleus (Austin, Tex.) · 2018Review
- Transplantation of Bone Marrow Mesenchymal Stem Cells Prevents Radiation-Induced Artery Injury by Suppressing Oxidative Stress and Inflammation.Oxidative medicine and cellular longevity · 2018Article
- MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation.EMBO molecular medicine · 2017Article
- The Role of Nrf2 in Cardiovascular Function and Disease.Oxidative medicine and cellular longevity · 2017Review
- Diabetes and ageing-induced vascular inflammation.The Journal of physiology · 2016Review
- Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice.Cardiovascular diabetology · 2015Article
- Diabetic cardiomyopathy and its prevention by nrf2: current status.Diabetes & metabolism journal · 2014Review
- Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ-induced diabetes.Journal of cellular and molecular medicine · 2014Article
- Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?Redox report : communications in free radical research · 2014Review
- Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.Oxidative medicine and cellular longevity · 2014Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study tested whether MG132 increases vascular nuclear factor E2-related factor-2 (Nrf2) expression and transcription to provide a therapeutic effect on diabetes-induced pathogenic changes in the aorta. To this end, three-month-old OVE26 diabetic and age-matched control mice were intraperitoneally injected with MG-132, 10 μ g/kg daily for 3 months. OVE26 transgenic type 1 diabetic mice develop hyperglycemia at 2-3 weeks of age and exhibit albuminuria at 3 months of age with mild increases in TNF- α expression and 3-NT accumulation in the aorta. Diabetes-induced significant increases in the wall thickness and structural derangement of aorta were found in OVE26 mice with significant increases in aortic oxidative and nitrosative damage, inflammation, and remodeling at 6 months of diabetes, but not at 3 months of diabetes. However, these pathological changes seen at the 6 months of diabetes were abolished in OVE26 mice treated with MG-132 for 3 months that were also associated with a significant increase in Nrf2 expression in the aorta as well as transcription of downstream genes. These results suggest that chronic treatment with low-dose MG132 can afford an effective therapy for diabetes-induced pathogenic changes in the aorta, which is associated with the increased Nrf2 expression and transcription.
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