ArticleJournal of immunology (Baltimore, Md. : 1950)2013
The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming.Human vaccines & immunotherapeutics · 2015Trial
- Trial
- Memory programming and new manufacturing paradigms in CAR-T cell therapy.Cancer gene therapy · 2026Review
- Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022Review
- Malaria-induced bacteremia as a consequence of multiple parasite survival strategies.Current research in microbial sciences · 2021Review
- The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development.Molecular and biochemical parasitology · 2021Review
- Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development.Parasite immunology · 2021Review
- Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity.Journal for immunotherapy of cancer · 2019Article
- Parasite load stemming from immunization route determines the duration of liver-stage immunity.Parasite immunology · 2019Article
- The appropriate frequency and function of decidual Tim-3Cell death & disease · 2019Article
- Identification of a Novel CD8 T Cell Epitope Derived fromFrontiers in immunology · 2018Article
- Infectious Sporozoites ofFrontiers in immunology · 2018Article
- Immune-mediated processes in neurodegeneration: where do we stand?Journal of neurology · 2016Review
- Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.Seminars in immunopathology · 2015Review
- Plasmodium cellular effector mechanisms and the hepatic microenvironment.Frontiers in microbiology · 2015Review
- Article
- Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Liver-Stage Specific Response among Endemic Populations: Diet and Immunity.Frontiers in immunology · 2015Review
- Memory T cells maintain protracted protection against malaria.Immunology letters · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably linked to long-lasting protective immunity. Studies of protective immunity among residents of malaria endemic areas indicate that memory responses to Plasmodium Ags are not adequately developed or maintained, as people who survive episodes of childhood malaria are still vulnerable to either persistent or intermittent malaria infections. In contrast, multiple exposures to radiation-attenuated Plasmodium berghei sporozoites (Pb γ-spz) induce long-lasting protective immunity to experimental sporozoite challenge. We previously demonstrated that sterile protection induced by Pb γ-spz is MHC class I-dependent and CD8 T cells are the key effectors. IFN-γ(+) CD8 T cells that arise in Pb γ-spz-immunized B6 mice are found predominantly in the liver and are sensitive to levels of liver-stage Ag depot and they express CD44(hi)CD62L(lo) markers indicative of effector/effector memory phenotype. The developmentally related central memory CD8 T (TCM) cells express elevated levels of CD122 (IL-15Rβ), which suggests that CD8 TCM cells depend on IL-15 for maintenance. Using IL-15-deficient mice, we demonstrate in this study that although protective immunity is inducible in these mice, protection is short-lived, mainly owing to the inability of CD8 TCM cells to survive in the IL-15-deficient milieu. We present a hypothesis consistent with a model whereby intrahepatic CD8 TCM cells, being maintained by IL-15-mediated survival and basal proliferation, are conscripted into the CD8 effector/effector memory T cell pool during subsequent infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.