ArticleThe Journal of experimental medicine2013
The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Absent the pre-B cell receptor checkpoint, the B-1a immunoglobulin CDR-H3 repertoire normalizes by convergent selection.Frontiers in immunology · 2026Article
- Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Article
- Age-related changes in antigen-specific natural antibodies are influenced by sex.Frontiers in immunology · 2022Article
- Development of a Prognostic Nomogram for Acute Myeloid Leukemia onInternational journal of general medicine · 2021Article
- Replacement of TCR Dβ With Immunoglobulin DFrontiers in immunology · 2020Article
- Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DFrontiers in immunology · 2020Article
- Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- On being the right size: antibody repertoire formation in the mouse and human.Immunogenetics · 2018Review
- In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101.Frontiers in immunology · 2018Article
- PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Defining Natural Antibodies.Frontiers in immunology · 2017Article
- Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells.Frontiers in immunology · 2017Article
- Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2016Article
- Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.Immunogenetics · 2016Article
- DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus Immunogenotypes.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The Global Self-Reactivity Profile of the Natural Antibody Repertoire Is Largely Independent of Germline DH Sequence.Frontiers in immunology · 2016Article
- Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Selection and physiological production of protective natural antibodies (NAbs) have been associated with exposure to endogenous antigens. The extent to which this association depends on germline NAb sequence is uncertain. Here we show that alterations in germline D(H) sequence can sever the association between the production of self-reactive NAbs and NAbs that afford protection against a pathogen. In unmanipulated hosts, the availability of the evolutionarily conserved DFL16.1 gene segment sequence profoundly affected the serum levels of NAbs against bacterial phosphorylcholine but not oxidized low-density lipoprotein. Mice with partially altered DFL16.1 sequence could use N nucleotides to recreate the amino acid sequence associated with the classical protective T15 idiotype–positive NAbs, whereas those without DFL16.1 could not. DFL16.1 gene-deficient mice proved more susceptible to challenge with live Streptococcus pneumoniae. Our findings indicate that although production of self-reactive NAbs can be independent of germline D(H) sequence, their capacity to provide protection against pathogens cannot. The potential relevance of these findings for the rational design of vaccines is discussed.
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