ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2013
Clinical analysis and interpretation of cancer genome data.
Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed.
- Association for Clinical Genomic Science (ACGS) guidelines for the classification of oncogenicity of somatic variants in cancer: recommendations by the UK somatic variant interpretation group (SVIG-UK).Journal of medical genetics · 2026Article
- From Genomic Exploration to Personalized Treatment: Next-Generation Sequencing in Oncology.Current issues in molecular biology · 2024Review
- Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors.Innovation (Cambridge (Mass.)) · 2024Article
- Utility of public knowledge bases for the interpretation of comprehensive tumor molecular profiling results.Clinical and experimental medicine · 2023Article
- Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Electronic Health Record Data in Cancer Learning Health Systems: Challenges and Opportunities.JCO clinical cancer informatics · 2022Review
- Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series.Diagnostics (Basel, Switzerland) · 2021Article
- Personalized Cancer Medicine in the Media: Sensationalism or Realistic Reporting?Journal of personalized medicine · 2021Article
- Utilization of Self-Diagnosis Health Chatbots in Real-World Settings: Case Study.Journal of medical Internet research · 2021Article
- A novel gene expression test method of minimizing breast cancer risk in reduced cost and time by improving SVM-RFE gene selection method combined with LASSO.Journal of integrative bioinformatics · 2020Article
- Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer.Nature medicine · 2020Article
- Current and future applications of liquid biopsy in nonsmall cell lung cancer from early to advanced stages.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study.Medical oncology (Northwood, London, England) · 2019Article
- Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study.Nature medicine · 2019Article
- Next-generation sequencing-based clinical sequencing: toward precision medicine in solid tumors.International journal of clinical oncology · 2019Review
- Article
- DynSig: Modelling Dynamic Signaling Alterations along Gene Pathways for Identifying Differential Pathways.Genes · 2018Article
- Noninvasive cancer biomarkers in solid malignancies: circulating tumor DNA-clinical utility, current limitations and future perspectives.Annals of translational medicine · 2018Article
- Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study.Briefings in bioinformatics · 2018Article
- Optimization of a microfluidics-based next generation sequencing assay for clinical oncology diagnostics.Annals of translational medicine · 2018Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The scale of tumor genomic profiling is rapidly outpacing human cognitive capacity to make clinical decisions without the aid of tools. New frameworks are needed to help researchers and clinicians process the information emerging from the explosive growth in both the number of tumor genetic variants routinely tested and the respective knowledge to interpret their clinical significance. We review the current state, limitations, and future trends in methods to support the clinical analysis and interpretation of cancer genomes. This includes the processes of genome-scale variant identification, including tools for sequence alignment, tumor-germline comparison, and molecular annotation of variants. The process of clinical interpretation of tumor variants includes classification of the effect of the variant, reporting the results to clinicians, and enabling the clinician to make a clinical decision based on the genomic information integrated with other clinical features. We describe existing knowledge bases, databases, algorithms, and tools for identification and visualization of tumor variants and their actionable subsets. With the decreasing cost of tumor gene mutation testing and the increasing number of actionable therapeutics, we expect the methods for analysis and interpretation of cancer genomes to continue to evolve to meet the needs of patient-centered clinical decision making. The science of computational cancer medicine is still in its infancy; however, there is a clear need to continue the development of knowledge bases, best practices, tools, and validation experiments for successful clinical implementation in oncology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.