ArticleThe American journal of tropical medicine and hygiene2013
Mathematical models of within-host and transmission dynamics to determine effects of malaria interventions in a variety of transmission settings.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The contribution of non-malarial febrile illness co-infections to Plasmodium falciparum case counts in health facilities in sub-Saharan Africa.Malaria journal · 2019Pooled it
- Agent-based models of malaria transmission: a systematic review.Malaria journal · 2018Pooled it
- In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies.Scientific reports · 2017Trial
- Multitask deep learning for the emulation and calibration of an agent-based malaria transmission model.PLoS computational biology · 2025Article
- A Probabilistic Synthesis of Malaria Epidemiology: Exposure, Infection, Parasite Densities, and Detection.medRxiv : the preprint server for health sciences · 2025Article
- Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa.Parasites & vectors · 2025Review
- Immunogenicity and transmission-blocking potential of quiescin sulfhydryl oxidase inFrontiers in cellular and infection microbiology · 2024Article
- Investigating the Impact of Irrigation on Malaria Vector Larval Habitats and Transmission Using a Hydrology-Based Model.GeoHealth · 2023Article
- Application of mathematical modelling to inform national malaria intervention planning in Nigeria.Malaria journal · 2023Article
- Prospective surveillance study to detect antimalarial drug resistance, gene deletions of diagnostic relevance and genetic diversity ofBMJ open · 2022Article
- Systems biology of malaria explored with nonhuman primates.Malaria journal · 2022Review
- Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo.Evolutionary applications · 2022Article
- Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria.Nature communications · 2021Article
- Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S.Malaria journal · 2021Review
- The impact of within-vector parasite development on the extrinsic incubation period.Royal Society open science · 2020Article
- Cost-effectiveness and public health impact of RTS,S/AS01Wellcome open research · 2020Article
- Critical transitions in malaria transmission models are consistently generated by superinfection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study.BMC infectious diseases · 2018Article
- The portfolio effect cushions mosquito populations and malaria transmission against vector control interventions.Malaria journal · 2018Article
- Impact of mass drug administration campaigns depends on interaction with seasonal human movement.International health · 2018Article
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1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A model for Anopheles population dynamics and malaria transmission is combined with a within-host dynamics microsolver to study baseline transmission, the effects of seasonality, and the impact of interventions. The Garki Project is recreated in simulation of the pre-intervention baseline and the different combinations of interventions deployed. Modifications are introduced, and longer project duration, extension of dry-season spraying, and transmission-blocking vaccines together achieve local elimination in some conditions. A variety of interventions are simulated in transmission settings that vary in transmission intensity and underlying seasonality. Adding vaccines to existing vector control efforts extends the ability to achieve elimination to higher baseline transmission and less favorable vector behavior. If one species of the Anopheles gambiae species complex feeds disproportionately outdoors for a given complex average behavior, vector control impacts are less than for a single species. Non-zero dry-season transmission limits seasonal oscillation in parasite dynamics and impact of wet-season interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.