ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2013
Serum C-peptide levels and risk of death among adults without diabetes mellitus.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Changes in Choline Metabolites and Ceramides in Response to a DASH-Style Diet in Older Adults.Nutrients · 2023Trial
- Trial
- C-peptide in Precision Diabetes Care and Beyond: A Comprehensive Review.Clinical medicine insights. Endocrinology and diabetes · 2026Review
- Characterizing echocardiographic abnormalities and their associated factors in patients with type 1 diabetes: a cross-sectional study.Cardiovascular diabetology · 2025Article
- Fasting plasma C-peptide correlates with body mass index, hsCRP, apolipoprotein B, and other atherogenic lipids in healthy individuals.Physiological reports · 2025Article
- The association of serum C-peptide with the risk of cardiovascular events: a meta-analysis and systematic review.Diabetology & metabolic syndrome · 2023Review
- Urinary c-peptide creatinine ratio (UCPCR) as a predictor of coronary artery disease in type 1 diabetes mellitus.Endocrinology, diabetes & metabolism · 2023Article
- Serum C-peptide level and the risk of cardiovascular diseases mortality and all-cause mortality: a meta-analysis and systematic review.Frontiers in cardiovascular medicine · 2023Review
- The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study.Cardiovascular diabetology · 2022Article
- Cholesterol and glucose profiles according to different fasting C-peptide levels: a cross-sectional analysis in a healthy cohort from the Czech Republic.Journal of applied biomedicine · 2021Article
- Higher fasting C-peptide is associated with post-stroke depression: a multicenter prospective cohort study.BMC neurology · 2021Article
- Lost in Translation: A Disconnect Between the Science and Medicare Coverage Criteria for Continuous Subcutaneous Insulin Infusion.Diabetes technology & therapeutics · 2021Article
- Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults.Frontiers in nutrition · 2021Article
- Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension.International journal of hypertension · 2021Article
- C-Peptide: A Mediator of the Association Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a Chinese Population With Normal Serum Uric Acid Levels.Frontiers in endocrinology · 2020Article
- Associations of serum C-peptide and insulin-like growth factor binding proteins-3 with breast cancer deaths.PloS one · 2020Article
- [C-peptide and cardiovascular mortality: systematic review and meta-analysisPéptido C y mortalidad cardiovascular: revisión sistemática y metanálisis].Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- C-Peptide and cardiovascular risk factors among young adults in a southern Brazilian cohort.BMC endocrine disorders · 2018Article
- [Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- The Association of Fasting Glucose, Insulin, and C-Peptide, with 19-Year Incidence of Coronary Heart Disease in Older Japanese-American Men; the Honolulu Heart Program.Geriatrics (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConnecting peptide (C-peptide) plays a role in early atherogenesis in patients with diabetes mellitus and may be a marker for cardiovascular morbidity and mortality in patients without diabetes. We investigated whether serum C-peptide levels are associated with all-cause, cardiovascular-related and coronary artery disease-related mortality in adults without diabetes.
methodsWe used data from the Third Nutrition and Health Examination Survey (NHANES III) and the NHANES III Linked Mortality File in the United States. We analyzed mortality data for 5902 participants aged 40 years and older with no history of diabetes and who had available serum C-peptide levels from the baseline examination. We grouped the participants by C-peptide quartile, and we performed Cox proportional hazards regression analysis. The primary outcome was all-cause, cardiovascular-related and coronary artery disease-related mortality.
resultsThe mean serum C-peptide level in the study sample was 0.78 (± standard deviation 0.47) nmol/L. The adjusted hazards ratio comparing the highest quartile with the lowest quartile was 1.80 (95% confidence interval [CI] 1.33-2.43) for all-cause mortality, 3.20 (95% CI 2.07-4.93) for cardiovascular-related mortality, and 2.73 (95% CI 1.55-4.82) for coronary artery disease-related mortality. Higher C-peptide levels were associated with increased mortality among strata of glycated hemoglobin and fasting serum glucose.
interpretationWe found an association between serum C-peptide levels and all-cause and cause-specific mortality among adults without diabetes at baseline. Our finding suggests that elevated C-peptide levels may be a predictor of death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.