ArticleDigestive diseases and sciences2013
No significant association between vitamin D and nonalcoholic fatty liver disease in a Chinese population.
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Vitamin D Sufficiency Revisited: Evidence of a Dose-Response Effect for MASLD in Adults at Risk.Nutrients · 2026Article
- Association between serum vitamin D concentration and liver fibrosis in diabetes mellitus patients: a cross-sectional study from the NHANES database.Acta diabetologica · 2024Article
- Article
- The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter.Journal of clinical medicine · 2021Article
- A Low Creatinine to Body Weight Ratio Predicts the Incident Nonalcoholic Fatty Liver Disease in Nonelderly Chinese without Obesity and Dyslipidemia: A Retrospective Study.Gastroenterology research and practice · 2020Article
- Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study.BMC gastroenterology · 2019Article
- Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Population.Pediatric gastroenterology, hepatology & nutrition · 2019Article
- The relationship between vitamin D level and hepatosteatosis in obese children.Northern clinics of Istanbul · 2019Article
- Calcium and vitamin DEuropean journal of nutrition · 2018Article
- Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease.Endocrine · 2017Article
- The Common Mechanisms of Sarcopenia and NAFLD.BioMed research international · 2017Review
- The serum vitamin D level is inversely correlated with nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2016Article
- Can skin exposure to sunlight prevent liver inflammation?Nutrients · 2015Review
- Association between vitamin D and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: results from a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Nonalcoholic fatty liver disease and aging: epidemiology to management.World journal of gastroenterology · 2014Review
- Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes.Acta pharmacologica Sinica · 2014Article
- Effect of Vitamin D Supplementation on C-reactive Protein in Patients with Nonalcoholic Fatty Liver.International journal of preventive medicine · 2014Article
- The association of vitamin D deficiency with non-alcoholic fatty liver disease.Clinics (Sao Paulo, Brazil) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome research evidence from Western populations suggests that lower vitamin D is associated with the prevalence and histologically assessed severity of nonalcoholic fatty liver disease (NAFLD).
aimsTo investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D status (deficiency <20 ng/ml; insufficiency 20-30 ng/ml; sufficiency >30 ng/ml) with the prevalence of NAFLD in study population of Chinese.
methodsSerum 25(OH)D, parathyroid hormone, lipids, liver enzymes, and anthropometric characteristics were measured in 1,248 subjects aged ≥ 20 years. NAFLD was diagnosed using abdominal ultrasound examination.
resultsThe prevalence of NAFLD was 30.3 % in the total study population, 37.9 % in the male subjects, and 20.8 % in the female subjects (P < 0.0001). Subjects with NAFLD had a significantly higher body mass index, higher levels of fasting blood glucose and liver enzymes, and a more atherogenic lipid profile. However, serum 25(OH)D concentrations were not significantly different between subjects with and without NAFLD (22.1 vs. 22.8 ng/ml, respectively; P = 0.21). In addition, a 10 ng/ml higher serum 25(OH)D concentrations [odds ratio (OR) 1.02, 95 % confidence interval (CI) 0.84-1.25, P = 0.82] or vitamin D status (vs. sufficiency: deficiency OR 0.86, 95 % CI 0.54-1.37, P = 0.52; insufficiency OR 0.96, 95 % CI 0.61-1.52, P = 0.87) were not significantly associated with the presence of NAFLD in the multivariate logistic regression analyses.
conclusionsSerum 25(OH)D concentrations or vitamin D status were not significantly associated with the presence of NAFLD. More studies are needed to elucidate the relationship between vitamin D and the occurrence of NAFLD in Chinese.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.