ArticleDigestive diseases and sciences2013
Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model.
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment.Nature reviews. Gastroenterology & hepatology · 2022Review
- The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders.International journal of molecular sciences · 2022Review
- Development of severe colitis in Takayasu arteritis treated with tocilizumab.Clinical rheumatology · 2022Review
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.Immunity · 2021Article
- Biological characteristics of IL-6 and related intestinal diseases.International journal of biological sciences · 2021Review
- Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.Gut and liver · 2019Article
- Immunomodulation of enteric neural function in irritable bowel syndrome.World journal of gastroenterology · 2015Review
- Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway.International journal of clinical and experimental pathology · 2015Article
- Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome.The Journal of physiology · 2014Article
- Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- An In Vivo and In Vitro Evaluation of the Mutual Interactions between the Lung and the Large Intestine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines.
aimsIn the present study, we aimed to investigate the effect of Interleukin-6 (IL-6) on colon motility in a rat model of depression induced by chronic unpredictable mild stress (CUMS).
methodsThe contraction of the circular muscle strips of proximal colon was monitored by a polygraph. IL-6 and IL-6 receptor (IL-6R) mRNA was assayed by real-time quantitative PCR. Immunohistochemistry staining was used to locate the IL-6 and IL-6R in the rat colon.
resultsIL-6 and IL-6R were expressed in the mucosal layer, smooth muscle cells, and myenteric plexus of the colon. Exogenous IL-6 (20 ng/ml) increased the contraction of the circular muscle strip. Pretreatment of tetrodotoxin (blocker of voltage-dependent Na(+) channel on nerve fiber) blocks the excitatory effect of IL-6 on the contraction of the colon in non-stressed rats, but partially inhibited IL-6-induced excitatory effect on the muscle strips in CUMS-treated rats.
conclusionsThese results suggest that IL-6-induced the contraction of the colonic strip by acting on the gut's nervous system and acting directly on the smooth muscle in rats with depression.
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