Evidence map›Paper›PMID 23589096›Full record

ArticleArchives of dermatological research2013

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.

Mary K Leonard, Natasha T Hill, Ethan D Grant, Madhavi P Kadakia

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mary K LeonardDepartment of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, 122 Diggs Laboratory, 3640 Colonel Glenn Highway, Dayton, OH, 45435, USA.
Natasha T Hill
Ethan D Grant
Madhavi P Kadakia
Wright State University · US

Funding

Role of DeltaNp63alpha in Vitamin D Mediated Cell Survival in Skin CancerR01CA154715 · NCI · WRIGHT STATE UNIVERSITY · PI KADAKIA, MADHAVI P · 2012 to 2016
$1.4M
NCI NIH HHS 1R01CA154715NCI NIH HHS R01 CA154715
6 · The paper itself

Abstract

ΔNp63α maintains the proliferative potential of keratinocytes by inhibiting the transcription and nuclear localization of the tumor suppressor PTEN as shown earlier by our laboratory. The goal of this study was to define the mechanisms by which ΔNp63α mediates the nuclear exclusion of PTEN. We demonstrate here that ΔNp63α reduces the ubiquitination of PTEN, a key signaling event in the nuclear translocation of PTEN. The decrease in ubiquitinated PTEN correlated with the ability of ΔNp63α to bind to neuronal precursor developmentally down regulated 4 (NEDD4) promoter and transcriptionally repress the E3 ubiquitin ligase NEDD4-1. Knockdown of NEDD4-1 in cultured keratinocytes was sufficient to attenuate the increase in nuclear PTEN observed upon silencing of ΔNp63α. In vivo examination of normal skin demonstrated that ΔNp63α and NEDD4-1 were both expressed in the basal layer of the epidermis and this correlated with nuclear exclusion of PTEN. Altogether, these studies suggest that ΔNp63α-mediated suppression of nuclear PTEN in basal layer keratinocytes occurs through repression of NEDD4-1.

Indexed as

Active Transport, Cell NucleusCell LineCell ProliferationDown-RegulationEndosomal Sorting Complexes Required for TransportEpidermisHumansKeratinocytesNedd4 Ubiquitin Protein LigasesPromoter Regions, GeneticPTEN PhosphohydrolaseSignal TransductionTranscription FactorsTumor Suppressor ProteinsUbiquitinationUbiquitin-Protein LigasesEndosomal Sorting Complexes Required for TransportNedd4 protein, humanNedd4 Ubiquitin Protein LigasesPTEN PhosphohydrolasePTEN protein, humanTP63 protein, humanTranscription FactorsTumor Suppressor ProteinsUbiquitin-Protein Ligases

Identifiers

PMID23589096
PMCPMC3779491
OpenAlexW2055293131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.