ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2013
A novel customizable modular bioreactor system for whole-heart cultivation under controlled 3D biomechanical stimulation.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Two Decades of Advances and Limitations in Organ Recellularization.Current issues in molecular biology · 2024Review
- Integrated biophysical matching of bacterial nanocellulose coronary artery bypass grafts towards bioinspired artery typical functions.Scientific reports · 2023Article
- Review
- Decellularized Extracellular Matrix Scaffolds for Cardiovascular Tissue Engineering: Current Techniques and Challenges.International journal of molecular sciences · 2022Review
- Bacterial Nanocellulose-Based Grafts for Cell Colonization Studies: An In Vitro Bioreactor Perfusion Model.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Ventricular stabilization with a customized decellularized cardiac ECM-based scaffold after myocardial infarction alters gene expression in a rodent LAD-ligation model.Frontiers in bioengineering and biotechnology · 2022Article
- Applications of Tissue Decellularization Techniques in Ventricular Myocardial Biofabrication.Frontiers in bioengineering and biotechnology · 2022Review
- Comparative Evaluation on Impacts of Fibronectin, Heparin-Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro.Nanomaterials (Basel, Switzerland) · 2021Article
- Oxygen Biosensors and Control in 3D Physiomimetic Experimental Models.Antioxidants (Basel, Switzerland) · 2021Review
- Integration of biological systems with electronic-mechanical assemblies.Acta biomaterialia · 2019Review
- Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration.Advanced healthcare materials · 2019Review
- A versatile modular bioreactor platform for Tissue Engineering.Biotechnology journal · 2017Article
- Bioengineering Hearts: Simple yet Complex.Current stem cell reports · 2017Review
- The Rapidly Evolving Concept of Whole Heart Engineering.Stem cells international · 2017Review
- Electrical and mechanical stimulation of cardiac cells and tissue constructs.Advanced drug delivery reviews · 2016Review
- Bioengineering Human Myocardium on Native Extracellular Matrix.Circulation research · 2016Article
- A review of cellularization strategies for tissue engineering of whole organs.Frontiers in bioengineering and biotechnology · 2015Review
- Decellularized scaffolds as a platform for bioengineered organs.Current opinion in organ transplantation · 2014Review
- Journal of Artificial Organs 2013: the year in review : Journal of Artificial Organs Editorial Committee.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2014Article
- Article
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Authors and funding
9 authors.
Funding
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Abstract
In the last decade, cardiovascular tissue engineering has made great progress developing new strategies for regenerative medicine applications. However, while tissue engineered heart valves are already entering the clinical routine, tissue engineered myocardial substitutes are still restrained to experimental approaches. In contrast to the heart valves, tissue engineered myocardium cannot be repopulated in vivo because of its biological complexity, requiring elaborate cultivation conditions ex vivo. Although new promising approaches-like the whole-heart decellularization concept-have entered the myocardial tissue engineering field, bioreactor technology needed for the generation of functional myocardial tissue still lags behind in the sense of user-friendly, flexible and low cost systems. Here, we present a novel customizable modular bioreactor system that can be used for whole-heart cultivation. Out of a commercially obtainable original equipment manufacturer platform we constructed a modular bioreactor system specifically aimed at the cultivation of decellularized whole-hearts through perfusion and controlled 3D biomechanical stimulation with a simple but highly flexible operation platform based on LabVIEW. The modular setup not only allows a wide range of variance regarding medium conditioning under controlled 3D myocardial stretching but can also easily be upgraded for e.g. electrophysiological monitoring or stimulation, allowing for a tailor-made low-cost myocardial bioreactor system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.