ArticleAnnals of internal medicine2013
Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications.
Article in Annals of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 518 papers, 8 of them syntheses that pooled it.
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Who cites it
518 citing papers in PubMed, 8 syntheses or guidelines pooled it, 870 citations in OpenAlex.
- Diagnostic performance of lumbar computed tomography Hounsfield unit thresholds for osteoporosis and osteopenia: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Artificial intelligence for opportunistic screening of osteoporosis across multiple imaging modalities: a systematic review.Frontiers in medicine · 2026Pooled it
- Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Opportunistic CT-based osteoporosis screening of the hip: a systematic review of diagnostic accuracy.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Evaluating the prognostic role of computed tomography Hounsfield units in anticipating spinal outcomes post-instrumentation: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- Pooled it
- Two-decade dialogue between artificial intelligence and osteoporosis: research trajectories and frontier projections under bibliometric and visual analysis.Frontiers in medicine · 2025Pooled it
- Diagnostic performance of radiomics for predicting osteoporosis in adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Low bone density and post-operative outcomes following revision total shoulder arthroplasty.Journal of shoulder and elbow arthroplasty · 2026Article
- Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.Renal failure · 2026Article
- Volumetric assessment from L2 to L4 improves the reliability and validity of body composition by CT.European journal of radiology · 2026Article
- Age- and sex-specific values of regional bone mineral density from opportunistic CT of the lower lumbar spine, pelvis, sacrum, and proximal femur.Skeletal radiology · 2026Article
- CT-based body composition enhances prognostic performance of PASO score for surgical outcome in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Repeatability of AI-quantified incidental findings on lung cancer screening CT scans in the NELSON trial.European radiology · 2026Article
- Development and evaluation of a simple CT-based DXA triage score for osteoporosis in candidates for lumbar spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Opportunistic lumbar vertebral CT attenuation is associated with intertrochanteric femur fracture occurrence and fracture instability in older adults.Skeletal radiology · 2026Article
- Precision management of gastrointestinal tumor-associated osteoporosis driven by cutting-edge technologies: Current status, challenges, and future prospects.World journal of methodology · 2026Review
- Artificial Intelligence-Driven Precision Bisphosphonate Therapy in Osteoporosis: Mechanisms, Clinical Applications, Risks, and Future Directions.Orthopaedic surgery · 2026Review
- Article
- Region-specific QCT thresholds for osteoporosis assessment in the thoracic spine: why lumbar cut-offs fail.BMC musculoskeletal disorders · 2026Article
458 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOsteoporosis is a prevalent but underdiagnosed condition.
objectiveTo evaluate computed tomography (CT)-derived bone mineral density (BMD) assessment compared with dual-energy x-ray absorptiometry (DXA) measures for identifying osteoporosis by using CT scans performed for other clinical indications.
designCross-sectional study.
settingSingle academic health center. PATIENTS: 1867 adults undergoing CT and DXA (n = 2067 pairs) within a 6-month period over 10 years. MEASUREMENTS: CT-attenuation values (in Hounsfield units [HU]) of trabecular bone between the T12 and L5 vertebral levels, with an emphasis on L1 measures (study test); DXA BMD measures (reference standard). Sagittal CT images assessed for moderate-to-severe vertebral fractures.
resultsCT-attenuation values were significantly lower at all vertebral levels for patients with DXA-defined osteoporosis (P < 0.001). An L1 CT-attenuation threshold of 160 HU or less was 90% sensitive and a threshold of 110 HU was more than 90% specific for distinguishing osteoporosis from osteopenia and normal BMD. Positive predictive values for osteoporosis were 68% or greater at L1 CT-attenuation thresholds less than 100 HU; negative predictive values were 99% at thresholds greater than 200 HU. Among 119 patients with at least 1 moderate-to-severe vertebral fracture, 62 (52.1%) had nonosteoporotic T-scores (DXA false-negative results), and most (97%) had L1 or mean T12 to L5 vertebral attenuation of 145 HU or less. Similar performance was seen at all vertebral levels. Intravenous contrast did not affect CT performance. LIMITATION: The potential benefits and costs of using the various CT-attenuation thresholds identified were not formally assessed.
conclusionAbdominal CT images obtained for other reasons that include the lumbar spine can be used to identify patients with osteoporosis or normal BMD without additional radiation exposure or cost. PRIMARY FUNDING SOURCE: National Institutes of Health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.