ArticleNeuroradiology2013
Detection of irreversible changes in susceptibility-weighted images after whole-brain irradiation of children.
Article in Neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Computational Fractal-Based Analysis of MR Susceptibility-Weighted Imaging (SWI) in Neuro-Oncology and Neurotraumatology.Advances in neurobiology · 2024Article
- Review
- Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy.European radiology · 2018Article
- Detection of cavernous malformations after whole-brain radiotherapy in primitive neuroectodermal tumor patients-comparing susceptibility-weighted imaging and T2 gradient-echo sequences.Neuroradiology · 2018Article
- T2*-based MR imaging (gradient echo or susceptibility-weighted imaging) in midline and off-midline intracranial germ cell tumors: a pilot study.Neuroradiology · 2018Article
- Relationship between radiation dose and microbleed formation in patients with malignant glioma.Radiation oncology (London, England) · 2017Article
- Novel loss of function mutation in KRIT1/CCM1 is associated with distinctly progressive cerebral and spinal cavernous malformations after radiochemotherapy for intracranial malignant germ cell tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Article
- Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of pediatric brain tumors.Neuro-oncology · 2017Article
- MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives.Journal of immunology research · 2017Review
- Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors.Neuro-oncology · 2016Article
- The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma.Neuro-oncology · 2016Article
- The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma.Seminars in radiation oncology · 2014Review
- Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhole-brain irradiation is part of the therapy protocol for patients with medulloblastomas. Side effects and complications of radiation can be detected by follow-up magnetic resonance imaging (MRI). Susceptibility-weighted images (SWI) can detect even very small amounts of residual blood that cannot be shown with conventional MRI. The purpose of this study was to determine when and where SWI lesions appear after whole-brain irradiation.
methodsMRI follow-up of seven patients with medulloblastoma who were treated with whole-brain irradiation were analyzed retrospectively. SWI were part of the initial and follow-up MRI protocol. De novo SWI lesions, localization, and development over time were documented.
resultsAt time of irradiation, mean age of the patients was 13 years (±4 years). Earliest SWI lesions were detected 4 months after radiation treatment. In all patients, SWI lesions accumulated over time, although the individual number of SWI lesions varied. No specific dissemination of SWI lesions was observed.
conclusionWhole-brain irradiation can cause relatively early dot-like SWI lesions. The lesions are irreversible and accumulate over time. Histopathological correlation and clinical impact of these SWI lesions should be investigated.
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