ArticleSpinal cord2013
Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T.
Article in Spinal cord, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Magnetic resonance spectroscopy in cervical spondylotic myelopathy: a systematic review of metabolite changes and clinical correlations.Frontiers in medicine · 2025Pooled it
- Evaluating tissue injury in cervical spondylotic myelopathy with spinal cord MRI: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Pooled it
- Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI.NeuroImage. Clinical · 2016Pooled it
- Trial
- Updates in current concepts in degenerative cervical myelopathy: a systematic review.Journal of spine surgery (Hong Kong) · 2024Review
- Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy.Journal of clinical medicine · 2023Review
- Degenerative cervical myelopathy: Where have we been? Where are we now? Where are we going?Acta neurochirurgica · 2023Review
- Clinical and Research MRI Techniques for Assessing Spinal Cord Integrity in Degenerative Cervical Myelopathy-A Scoping Review.Biomedicines · 2022Article
- Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review.Journal of clinical medicine · 2022Review
- Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9].Global spine journal · 2022Article
- Neuroimaging features in inflammatory myelopathies: A review.Frontiers in neurology · 2022Review
- Article
- Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Article
- Review
- Are Magnetic Resonance Imaging Technologies Crucial to Our Understanding of Spinal Conditions?The Journal of orthopaedic and sports physical therapy · 2019Article
- Reproducibility, temporal stability, and functional correlation of diffusion MR measurements within the spinal cord in patients with asymptomatic cervical stenosis or cervical myelopathy.Journal of neurosurgery. Spine · 2018Observational
- Metabolic Imaging Using Proton Magnetic Spectroscopy as a Predictor of Outcome After Surgery for Cervical Spondylotic Myelopathy.Clinical spine surgery · 2017Article
- Advancements in Imaging Technology: Do They (or Will They) Equate to Advancements in Our Knowledge of Recovery in Whiplash?The Journal of orthopaedic and sports physical therapy · 2016Article
- Application of magnetic resonance imaging in cervical spondylotic myelopathy.World journal of radiology · 2014Review
- Spinal cord injury: how can we improve the classification and quantification of its severity and prognosis?Journal of neurotrauma · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
designA single-center magnetic resonance imaging and spectroscopic study involving 21 patients with advanced cervical spondylosis and 11 healthy controls.
objectiveWe assessed the utility of magnetic resonance spectroscopy (MRS) to quantify biochemical changes within the spinal cord and serve as a potential biomarker in patients with cervical spondylosis with or without T2 hyperintensity within the cord.
settingLos Angeles, California, USA.
methodsTwenty-one patients with cervical spondylosis and eleven healthy controls were evaluated. Single-voxel MRS was performed in the cervical cord. Morphometry of the spinal canal space was measured. N-Acetyl aspartylglutamic acid (NAA), choline (Cho), myo-inositol (Myo-I), glutamine-glutamate complex (Glx) and lactate metabolite concentration ratios with respect to total creatine (Cr) were quantified using an LC model algorithm and compared between healthy controls and spondylosis patients. Correlation of MRS metabolites with modified Japanese Orthopaedic Association (mJOA) score was also performed.
resultsThe spinal canal space was significantly different between patients and controls (analysis of variance (ANOVA), P<0.0001). Total Cho-to-Cr ratio was significantly elevated in patients with spondylosis and T2-hyperintensity compared with healthy controls (ANOVA, P<0.01). A significantly higher Cho-to-NAA ratio was observed in spondylosis patients compared with healthy controls (ANOVA, P<0.01). Slightly elevated Glx and Myo-I were encountered in patients with stenosis without T2 hyperintensity. A linear correlation between Cho-NAA ratio and mJOA was also observed (P<0.01).
conclusionMRS appears sensitive to biochemical changes occurring in advanced cervical spondylosis patients. The Cho/NAA ratio was significantly correlated with the mJOA score, providing a potentially clinically useful radiographical biomarker for the management of advanced cervical spondylosis patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.