ArticleEuropean journal of clinical pharmacology2013
Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Global prevalence of polypharmacy and potentially inappropriate medication in older patients with dementia: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Identifying potentially inappropriate prescribing in older people with dementia: a systematic review.European journal of clinical pharmacology · 2019Pooled it
- Use of Benzodiazepines in Alzheimer's Disease: A Systematic Review of Literature.The international journal of neuropsychopharmacology · 2015Pooled it
- Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review.Current clinical pharmacology · 2015Pooled it
- Sex and gender differences in access, quality of care, and effectiveness of treatment in dementia: a scoping review of studies up to 2024.Archives of public health = Archives belges de sante publique · 2025Article
- Inequalities in the Quality and Safety of Post-Diagnostic Primary Care for People With Dementia: A Scoping Review.International journal of geriatric psychiatry · 2024Article
- Risk of falls or fall-related injuries associated with potentially inappropriate medication use among older adults with dementia.BMC geriatrics · 2024Article
- Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies.Health technology assessment (Winchester, England) · 2021Article
- Risk factors associated with drug therapy among elderly people with Alzheimer's disease: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2020Article
- Potentially inappropriate prescribing in dementia: a state-of-the-art review since 2007.BMJ open · 2020Review
- Drug related problems in older adults living with dementia.PloS one · 2020Article
- Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study.Clinical interventions in aging · 2019Article
- Sex and gender differences in polypharmacy in persons with dementia: A scoping review.SAGE open medicine · 2019Article
- Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease.Journal of personalized medicine · 2018Review
- Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia.European journal of clinical pharmacology · 2017Article
- Charlson Comorbidity Index, inappropriate medication use and cognitive impairment : Bermuda Triangle.Wiener klinische Wochenschrift · 2017Article
- Anticholinergic drugs and functional, cognitive impairment and behavioral disturbances in patients from a memory clinic with subjective cognitive decline or neurocognitive disorders.Alzheimer's research & therapy · 2017Article
- An evaluation of the prevalence of potentially inappropriate medications in older people with cognitive impairment living in Northern Sweden using the EU(7)-PIM list.European journal of clinical pharmacology · 2017Article
- Article
- Risk Factors for Initiation of Potentially Inappropriate Medications in Community-Dwelling Older Adults with and without Alzheimer's Disease.Drugs & aging · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFew studies have investigated potentially inappropriate medication (PIM) use in patients with Alzheimer's disease (AD). The aim of our study was to assess the prevalence of PIM in community-dwelling patients diagnosed with mild-to-moderate AD and identify the clinical factors associated with PIM prescriptions.
methodsREAL.FR is a 4-year, prospective, multicenter French cohort of AD patients recruited in centers of expertise. We analyzed patient baseline data at entry into the study. PIMs were assessed using the Laroche list. A multivariate logistic regression was conducted to assess factors associated with PIMs.
resultsA total of 684 AD patients were enrolled in the study [mean age 77.9 ± 6.8 years, 486 (71.0 %) females]. According to the Laroche list, 46.8 % [95 % confidence interval (CI) 43.0-50.5 %] of the patients had at least one PIM. "Cerebral vasodilators" were the most widely used class of PIM, accounting for 24.0 % (95 % CI 20.9-27.3 %) of all prescriptions, followed by atropinic drugs (17.0 %, 95 % CI 14.1-19.8 %) and long half-life benzodiazepines (8.5 %, 95 % CI 6.4-10.6 %). Atropinic drugs were associated with cholinesterase inhibitors in 16 % of patients. In the multivariate analysis, only two factors, namely, female gender [odds ratio (OR) 1.5, 95 % CI 1.1-2.2] and polypharmacy (≥5 drugs; OR 3.6, 95 % CI 2.6-4.5) were associated with prescriptions for PIMs.
conclusionsThese results reveal that approximately one out of two community-dwelling patients with mild-to-moderate AD treated by AD specialists use PIMs. They also indicate that the characteristics of the disease and the pharmacodynamic/pharmacokinetic profile of the drugs prescribed are not sufficiently taken into account by physicians when prescribing for AD patients.
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