ArticleEuropean journal of clinical pharmacology2013
Adherence to preventive statin therapy according to socioeconomic position.
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease.PloS one · 2019Pooled it
- Statin treatment, new-onset diabetes, and other adverse effects: a systematic review.Current cardiology reports · 2014Pooled it
- Mental stress as a trigger of cardiovascular events: A narrative review.European journal of clinical investigation · 2026Review
- Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025Review
- Sex-based utilization of guideline recommended statin therapy and cardiovascular disease outcomes: Data from a multisite healthcare network primary prevention cohort.American journal of preventive cardiology · 2024Article
- Myocardial infarction care in low and high socioeconomic environments: claims data analysis.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Article
- Article
- Statins use amidst the pandemic: prescribing, dispensing, adherence, persistence, and correlation with COVID-19 statistics in nationwide real-world data from Poland.Frontiers in pharmacology · 2024Article
- Out-of-pocket expenditure on community healthcare services at end-of-life among decedents from cardiovascular disease in six European countries and Israel.Health economics review · 2023Article
- Appropriate Use of Primary Statin Preventive Therapy Among Patients with High Atherosclerosis-Related Cardiovascular Disease Risks: Cross-Sectional Study, Northeast Ethiopia.Vascular health and risk management · 2023Article
- Towards better reporting of the proportion of days covered method in cardiovascular medication adherence: A scoping review and new tool TEN-SPIDERS.British journal of clinical pharmacology · 2022Article
- AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis.Biomedicines · 2022Review
- Adherence to Statin Therapy and Attainment of LDL Cholesterol Targets in an Outpatient Population of Type 2 Diabetes Patients: Analysis in the DIAbetes and LifEstyle Cohort Twente (DIALECT).Frontiers in pharmacology · 2022Article
- Helicopter emergency medical services missions to islands and the mainland during a 3-year period in Denmark: a population-based study on patient and sociodemographic characteristics, comorbidity, and use of healthcare services.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Regularity and Continuity of GP Contacts and Use of Statins Amongst People at Risk of Cardiovascular Events.Journal of general internal medicine · 2021 · on this mapObservational
- Modelling tool to support decision-making in the NHS Health Check programme: workshops, systematic review and co-production with users.Health technology assessment (Winchester, England) · 2021Article
- Article
- Socioeconomic position is associated with surgical treatment of open fractures of the lower limb: results from a Swedish population-based study.Acta orthopaedica · 2020Article
- Socioeconomic Factors, Secondary Prevention Medication, and Long-Term Survival After Coronary Artery Bypass Grafting: A Population-Based Cohort Study From the SWEDEHEART Registry.Journal of the American Heart Association · 2020Article
- Association of Statin Use with Increased Risk of Musculoskeletal Conditions: A Retrospective Cohort Study.Drug safety · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore whether long-term adherence to preventive statin therapy depends on socioeconomic position (SEP).
methodsA cohort of individuals without established cardiovascular disease (CVD) or diabetes initiating preventive statin therapy during 2002-2005 was followed in the individual-level Danish registries for 4 years or until censoring events (death, emigration, CVD or diabetes). Only individuals aged 40-84 years for whom information was available on the SEP indicators, education and income were included (N = 76,038). Two different aspects of poor adherence were applied as outcome measures: (1) Proportion of days covered (PDC) with medication below 80 %, assuming a daily dose of one tablet (continuity); (2) Discontinuation defined as a gap between two consecutive prescriptions exceeding 365 days (persistence). Stratum-specific logistic regression analyses were applied to estimate the odds ratio (OR) for PDC <80 % across SEP, adjusting for age and hypertension. Hazard ratio (HR) for discontinuation was estimated by Cox regression analyses.
resultsAdjusting mutually for income and education, the OR for PDC <80 % decreased with increasing income. Comparing the highest income quintile with the lowest, the OR were 0.64 (95 % Confidence Interval 0.64-0.65) and 0.73 (0.73-0.74) in men aged 40-64 and 65-84 years, respectively; in women, the figures were 0.79 (0.79-0.79) and 0.95 (0.94-0.95), respectively. While observed increases in adherence with longer education in unadjusted analyses were attenuated after adjustment for income among men, the potential inverse relationship between length of education and adherence was enhanced among women. Applying discontinuation as outcome, analogous differences were demonstrated.
conclusionAdherence to preventive statin therapy in Denmark decreases with decreasing income-especially in men aged 40-64 years.
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Registered trials
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