ArticlePflugers Archiv : European journal of physiology2013
Visualization of fast calcium oscillations in the parafascicular nucleus.
Article in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus.Cellular and molecular life sciences : CMLS · 2019Article
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Bottom-up gamma and bipolar disorder, clinical and neuroepigenetic implications.Bipolar disorders · 2019Review
- Class II histone deacetylases require P/Q-type CaScientific reports · 2018Article
- Arousal and drug abuse.Behavioural brain research · 2017Review
- Bottom-up gamma and stages of waking.Medical hypotheses · 2017Article
- Differential alterations of intracellular [CaTranslational brain rhythmicity · 2017Article
- Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons.Physiological reports · 2016Article
- Bottom-up Gamma: the Pedunculopontine Nucleus and Reticular Activating System.Translational brain rhythmicity · 2016Article
- Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder.Journal of neurophysiology · 2015Article
- Gamma band activity in the RAS-intracellular mechanisms.Experimental brain research · 2014Review
- Pedunculopontine Nucleus Gamma Band Activity-Preconscious Awareness, Waking, and REM Sleep.Frontiers in neurology · 2014Review
- Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- The 10 Hz Frequency: A Fulcrum For Transitional Brain States.Translational brain rhythmicityArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The parafascicular nucleus (Pf) is an ascending target of the pedunculopontine nucleus (PPN) and is part of the "non-specific" intralaminar thalamus. The PPN, part of the reticular activating system, is mainly involved in waking and rapid eye movement sleep. Gamma oscillations are evident in all Pf neurons and mediated by high threshold voltage-dependent N- and P/Q-type calcium channels. We tested the hypothesis that high-speed calcium imaging would reveal calcium-mediated oscillations in synchrony with patch clamp recorded oscillations during depolarizing current ramps. Patch-clamped 9 to 19-day-old rat Pf neurons (n = 148, dye filled n = 61, control n = 87) were filled with Fura 2, Bis Fura, or Oregon Green BAPTA-1. Calcium transients were generated during depolarizing current ramps and visualized with a high-speed, wide-field fluorescence imaging system. Cells manifested calcium transients with oscillations in both somatic and proximal dendrite fluorescence recordings. Fluorescent calcium transients were blocked with the nonspecific calcium channel blocker, cadmium, or the combination of ω-Agatoxin-IVA (AgA), a specific P/Q-type calcium channel blocker and ω-conotoxin-GVIA (CgTx), a specific N-type calcium channel blocker. We developed a viable methodology for studying high-speed oscillations without the use of multi-photon imaging systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.