ArticleGigaScience2012
Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer.
Article in GigaScience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 168 citations in OpenAlex.
- Multi-organ single-cell analysis of preferential expression of CAKUT genes.BMC nephrology · 2026Article
- Cancer stem cells: landscape, challenges and emerging therapeutic innovations.Signal transduction and targeted therapy · 2025Review
- Single-cell omics: experimental workflow, data analyses and applications.Science China. Life sciences · 2025Review
- Mugen-UMAP: UMAP visualization and clustering of mutated genes in single-cell DNA sequencing data.BMC bioinformatics · 2024Article
- Clinical implications of single cell sequencing for bladder cancer.Oncology research · 2024Review
- Single-cell phylogenies reveal changes in the evolutionary rate within cancer and healthy tissues.Cell genomics · 2023Article
- Computational single cell oncology: state of the art.Frontiers in genetics · 2023Review
- Application of single-cell sequencing to the research of tumor microenvironment.Frontiers in immunology · 2023Review
- Grave-to-cradle: human embryonic lineage tracing from the postmortem body.Experimental & molecular medicine · 2023Review
- Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter.Developmental cell · 2022Article
- Scelestial: Fast and accurate single-cell lineage tree inference based on a Steiner tree approximation algorithm.PLoS computational biology · 2022Article
- HBV genome-enriched single cell sequencing revealed heterogeneity in HBV-driven hepatocellular carcinoma (HCC).BMC medical genomics · 2022Article
- Single-Cell Sequencing Reveals that DBI is the Key Gene and Potential Therapeutic Target in Quiescent Bladder Cancer Stem Cells.Frontiers in genetics · 2022Article
- Single-cell sequencing technologies in bladder cancer research: Applications and challenges.Frontiers in genetics · 2022Review
- Somatic variant calling from single-cell DNA sequencing data.Computational and structural biotechnology journal · 2022Review
- Studying the History of Tumor Evolution from Single-Cell Sequencing Data by Exploring the Space of Binary Matrices.Journal of computational biology : a journal of computational molecular cell biology · 2021Article
- Applications of Single-Cell DNA Sequencing.Annual review of genomics and human genetics · 2021Review
- Review
- Experimental and bioinformatics considerations in cancer application of single cell genomics.Computational and structural biotechnology journal · 2021Article
- Advancing Cancer Research and Medicine with Single-Cell Genomics.Cancer cell · 2020Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 12 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancers arise through an evolutionary process in which cell populations are subjected to selection; however, to date, the process of bladder cancer, which is one of the most common cancers in the world, remains unknown at a single-cell level.
resultsWe carried out single-cell exome sequencing of 66 individual tumor cells from a muscle-invasive bladder transitional cell carcinoma (TCC). Analyses of the somatic mutant allele frequency spectrum and clonal structure revealed that the tumor cells were derived from a single ancestral cell, but that subsequent evolution occurred, leading to two distinct tumor cell subpopulations. By analyzing recurrently mutant genes in an additional cohort of 99 TCC tumors, we identified genes that might play roles in the maintenance of the ancestral clone and in the muscle-invasive capability of subclones of this bladder cancer, respectively.
conclusionsThis work provides a new approach of investigating the genetic details of bladder tumoral changes at the single-cell level and a new method for assessing bladder cancer evolution at a cell-population level.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.