Trial reportRadiation oncology (London, England)2013
Total Body Irradiation (TBI) using Helical Tomotherapy in children and young adults undergoing stem cell transplantation.
Trial report in Radiation oncology (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 108 citations in OpenAlex.
- Total body irradiation across conditioning intensities: historical context, dose-fractionation strategy, and the role of the chemotherapy backbone.Bone marrow transplantation · 2026Article
- Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) Into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report From the National Clinical Trials Network.International journal of radiation oncology, biology, physics · 2026Article
- Comparative analysis of kVCT- and MVCT-guided helical tomotherapy for total body irradiation: evaluation of process times and residual setup errors.Journal of radiation research · 2025Article
- Evaluation of superficial tumor treatment using radixact with the kilovoltage computed tomography system: dosimetric and clinical feasibility of super stuff bolus.Frontiers in oncology · 2025Article
- Development of an external system for monitoring the couch speed in radiotherapy using continuous bed movement.Journal of applied clinical medical physics · 2024Article
- A novel AP/PA total body irradiation technique using abutting IMRT fields at extended SSD.Journal of applied clinical medical physics · 2024Article
- Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.Frontiers in oncology · 2024Article
- Whole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics.Journal of cancer research and clinical oncology · 2023Article
- Investigation of total skin helical tomotherapy using a 3D-printed total skin bolus.Biomedical engineering online · 2023Article
- Optimal Combination of Pitch, Modulation Factor and Dosimetric Considerations in Treatment Planning for Total Body Irradiation Using Helical Tomotherapy.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- The top 100 most cited articles in helical tomotherapy: a scoping review.Frontiers in oncology · 2023Article
- Lung sparing and ribcage coverage in total body irradiation delivered by helical tomotherapy.European journal of medical research · 2022Article
- Outcomes of allogeneic haematopoietic stem cell transplantation with intensity-modulated total body irradiation by helical tomotherapy: a 2-year prospective follow-up study.Annals of medicine · 2022Article
- Article
- Effect of total body irradiation lung block parameters on lung doses using three-dimensional dosimetry.Journal of applied clinical medical physics · 2022Article
- Two compound techniques for total body irradiation.Technical innovations & patient support in radiation oncology · 2022Article
- Clinical study of total bone marrow combined with total lymphatic irradiation pretreatment based on tomotherapy in hematopoietic stem cell transplantation of acute leukemia.Frontiers in oncology · 2022Article
- Optimized Conformal Total Body Irradiation methods with Helical TomoTherapy and Elekta VMAT: Implementation, Imaging, Planning and Dose Delivery for Pediatric Patients.Frontiers in oncology · 2022Article
- Impact of lung block shape on cardiac dose for total body irradiation.Physics and imaging in radiation oncology · 2022Article
- Long-term follow up of patients with hematological malignancies treated with total body irradiation using intensity modulated radiation therapy.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEstablishing Total Body Irradiation (TBI) using Helical Tomotherapy (HT) to gain better control over dose distribution and homogeneity and to individually spare organs at risk. Because of their limited body length the technique seems especially eligible in juvenile patients. PATIENTS AND
methodsThe cohort consisted of 10 patients, 6 female and 4 male, aged 4 - 22 y with acute lymphoblastic- (ALL) or acute myeloic leukemia (AML). All patients presented with high risk disease features. Body length in treatment position ranged from 110-180 cm. Two Gy single dose was applied BID to a total dose of 12 Gy. Dose volume constraint for the PTV was 95% dose coverage for 95% of the volume. The lungs were spared to a mean dose of [less than or equal to] 10 Gy. Patients were positioned in a vac-loc bag in supine position with a 3-point head mask.
resultsAverage D95 to the PTV was 11.7 Gy corresponding to a mean coverage of the PTV of 97.5%. Dmean for the lungs was 9.14 Gy. Grade 3-4 side effects were not observed.
conclusionsTBI using HT is feasible and well tolerated. A benefit could be demonstrated with regard to dose distribution and homogeneity and the selective dose-reduction to organs at risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.