ArticleJournal of neuroengineering and rehabilitation2013
Impact of sub-thalamic nucleus deep brain stimulation on dual tasking gait in Parkinson's disease.
Article in Journal of neuroengineering and rehabilitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deep brain stimulation improves gait velocity in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2016Pooled it
- Non-motor symptoms burden and motor recovery following STN-DBS in Parkinson's disease: a data-driven longitudinal analysis.Journal of neurology · 2026Article
- The effect of subthalamic nucleus deep brain stimulation and dopaminergic treatment on dual-task manual dexterity in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Muscle synergies in Parkinson's disease before and after the deep brain stimulation of the bilateral subthalamic nucleus.Scientific reports · 2023Article
- Troubleshooting Gait Disturbances in Parkinson's Disease With Deep Brain Stimulation.Frontiers in human neuroscience · 2022Review
- Effects of Exergaming on Attentional Deficits and Dual-Tasking in Parkinson's Disease.Frontiers in neurology · 2019Article
- Association between Community Ambulation Walking Patterns and Cognitive Function in Patients with Parkinson's Disease: Further Insights into Motor-Cognitive Links.Parkinson's disease · 2015Article
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Authors and funding
4 authors.
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Abstract
backgroundThe beneficial effects of bilateral sub-thalamic nucleus deep brain stimulation on motor function and gait in advanced Parkinson's disease are established. Less is known about the effect of stimulation on cognitive function and the capacity to walk while dual tasking, an ability that has been related to fall risk. Everyday walking takes place in complex environments that often require multi-tasking. Hence, dual tasking gait performance reflects everyday ambulation as well as gait automaticity. The purpose of this study was to examine the impact of sub-thalamic nucleus deep brain stimulation on dual task walking in patients with advanced Parkinson's disease.
methodsGait was assessed using a performance-based test and by quantifying single-task and dual task walking conditions in 28 patients with advanced Parkinson's disease. These tests were conducted in 4 conditions: "OFF" medication, with the stimulator turned on and off, and "ON" medication, with the stimulator turned on and off. A previously validated, computerized neuro-psychological battery assessed executive function, attention and memory "OFF" and "ON" deep brain stimulation, after subjects took their anti-Parkinsonian medications.
resultsStimulation improved motor function and the spatiotemporal parameters of gait (e.g., gait speed) during both single-task and dual task walking conditions. Attention improved, but executive function did not. The dual task effect on gait did not change in response to stimulation. For example, during serial 3 subtractions, gait speed was reduced by -0.20 ± 0.14 m/sec while OFF DBS and OFF meds and by -0.22 ± 0.14 m/sec when the DBS was turned on (p = 0.648). Similarly, ON medication, serial 3 subtractions reduced gait speed by -0.20 ± 0.16 m/sec OFF DBS and by -0.22 ± 0.09 m/sec ON DBS (p = 0.543).
conclusionsBilateral sub-thalamic nucleus deep brain stimulation improves motor symptoms, certain features of gait and even some aspects of cognitive function. However, stimulation apparently fails to reduce the negative impact of a dual task on walking abilities. These findings provide new insight into the effects of deep brain stimulation on gait during cognitively challenging conditions and everyday walking.
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