ArticleBioMed research international2013
Titanium surface coating with a laminin-derived functional peptide promotes bone cell adhesion.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Synergy between Laminin-Derived Elastin-like Polypeptides (LELPs) Optimizes Cell Spreading.Biomacromolecules · 2024Article
- Synthesis of bone biocompatible implants using human adipose-derived mesenchymal stem cells (hADMSCs) and PCL/laminin scaffold substrate.Iranian journal of basic medical sciences · 2024Article
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- Preparation and Characterization of Biomimetic Functional Scaffold with Gradient Structure for Osteochondral Defect Repair.Bioengineering (Basel, Switzerland) · 2023Review
- Multipotential Role of Growth Factor Mimetic Peptides for Osteochondral Tissue Engineering.International journal of molecular sciences · 2022Review
- The Deposition of a Lectin fromBiomolecules · 2021Article
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- Synergic effects of decellularized bone matrix, hydroxyapatite, and extracellular vesicles on repairing of the rabbit mandibular bone defect model.Journal of translational medicine · 2020Article
- The role of extracelluar matrix in osteosarcoma progression and metastasis.Journal of experimental & clinical cancer research : CR · 2020Review
- Human Salivary Histatin-1 Promotes Osteogenic Cell Spreading on Both Bio-Inert Substrates and Titanium SLA Surfaces.Frontiers in bioengineering and biotechnology · 2020Article
- Laminin-Modified Dental Pulp Extracellular Matrix for Dental Pulp Regeneration.Frontiers in bioengineering and biotechnology · 2020Article
- Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration.Materials (Basel, Switzerland) · 2019Review
- Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses.Materials (Basel, Switzerland) · 2019Article
- Osteogenic Cell Behavior on Titanium Surfaces in Hard Tissue.Journal of clinical medicine · 2019Article
- Gene profiling of bone around orthodontic mini-implants by RNA-sequencing analysis.BioMed research international · 2015Article
- Reality of dental implant surface modification: a short literature review.The open biomedical engineering journal · 2014Article
- Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laminin-derived peptide coatings can enhance epithelial cell adhesion to implants, and the positive effect of these peptides on bone cell adhesion has been anticipated. The purpose of this study was to evaluate the improvement in bone cell attachment to and activity on titanium (Ti) scaffolds coated with a laminin-derived functional peptide, Ln2-P3 (the DLTIDDSYWYRI motif). Four Ti disc surfaces were prepared, and a human osteosarcoma (HOS) cell attachment test was performed to select two candidate surfaces for peptide coating. These two candidates were then coated with Ln2-P3 peptide, a scrambled peptide, or left uncoated to measure cell attachment to each surface, following which one surface was chosen to assess alkaline phosphatase (ALP) activity and osteogenic marker gene expression with quantitative real-time PCR. On the commercially pure Ti surface, the Ln2-P3 coating significantly increased cellular ALP activity and the expression levels of ALP and bone sialoprotein mRNA as compared with the scrambled peptide-coated and uncoated surfaces. In conclusion, although further in vivo studies are needed, the findings of this in vitro study indicate that the Ln2-P3-coated implant surface promotes bone cell adhesion, which has clinical implications for reducing the overall treatment time of dental implant therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.