ArticleBioMed research international2013
Signal propagation in protein interaction network during colorectal cancer progression.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Identification and Analysis of Glioblastoma Biomarkers Based on Single Cell Sequencing.Frontiers in bioengineering and biotechnology · 2020Article
- Identification and Analysis of the Blood lncRNA Signature for Liver Cirrhosis and Hepatocellular Carcinoma.Frontiers in genetics · 2020Article
- The Methylation Pattern for Knee and Hip Osteoarthritis.Frontiers in cell and developmental biology · 2020Article
- Identification of the copy number variant biomarkers for breast cancer subtypes.Molecular genetics and genomics : MGG · 2019Article
- The early detection of asthma based on blood gene expression.Molecular biology reports · 2019Article
- The transcriptome difference between colorectal tumor and normal tissues revealed by single-cell sequencing.Journal of Cancer · 2019Article
- The blood transcriptional signature for active and latent tuberculosis.Infection and drug resistance · 2019Article
- The Gene Expression Biomarkers for Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease.Frontiers in genetics · 2019Article
- Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer.Oncology letters · 2018Article
- Identification and Analysis of Blood Gene Expression Signature for Osteoarthritis With Advanced Feature Selection Methods.Frontiers in genetics · 2018Article
- Identification of the predictive genes for the response of colorectal cancer patients to FOLFOX therapy.OncoTargets and therapy · 2018Article
- Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.OncoTargets and therapy · 2018Article
- iAFP-Ense: An Ensemble Classifier for Identifying Antifreeze Protein by Incorporating Grey Model and PSSM into PseAAC.The Journal of membrane biology · 2016Article
- Biological Networks for Cancer Candidate Biomarkers Discovery.Cancer informatics · 2016Review
- Genetic differences among ethnic groups.BMC genomics · 2015Article
- Protein remote homology detection by combining Chou's distance-pair pseudo amino acid composition and principal component analysis.Molecular genetics and genomics : MGG · 2015Article
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6 authors.
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Abstract
Colorectal cancer is generally categorized into the following four stages according to its development or serious degree: Dukes A, B, C, and D. Since different stage of colorectal cancer actually corresponds to different activated region of the network, the transition of different network states may reflect its pathological changes. In view of this, we compared the gene expressions among the colorectal cancer patients in the aforementioned four stages and obtained the early and late stage biomarkers, respectively. Subsequently, the two kinds of biomarkers were both mapped onto the protein interaction network. If an early biomarker and a late biomarker were close in the network and also if their expression levels were correlated in the Dukes B and C patients, then a signal propagation path from the early stage biomarker to the late one was identified. Many transition genes in the signal propagation paths were involved with the signal transduction, cell communication, and cellular process regulation. Some transition hubs were known as colorectal cancer genes. The findings reported here may provide useful insights for revealing the mechanism of colorectal cancer progression at the cellular systems biology level.
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