ArticlePloS one2013
Microbiological and molecular characterization of Staphylococcus hominis isolates from blood.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
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- Unveiling the interplay among skin microbiota, cytokines, and T2DM: an insightful Mendelian randomization study.Nutrition & metabolism · 2025Article
- The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.Scientific reports · 2025Article
- Detection ofPathogens (Basel, Switzerland) · 2024Article
- Comparative Genomic Analysis of a Multidrug-ResistantPathogens (Basel, Switzerland) · 2022Article
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- Novel Organization of the Staphylococcal Cassette ChromosomeMicrobiology spectrum · 2022Article
- Coagulase-Negative Staphylococci Clones Are Widely Distributed in the Hospital and Community.Pathogens (Basel, Switzerland) · 2021Article
- Identification of Microorganisms from Several Surfaces by MALDI-TOF MS:Microorganisms · 2021Article
- Staphylococcal species less frequently isolated from human clinical specimens - are they a threat for hospital patients?BMC infectious diseases · 2020Article
- Bacterial Biodiversity of Extra Virgin Olive Oils and Their Potential Biotechnological Exploitation.Microorganisms · 2020Article
- Staphylococcus hominis subspecies can be identified by SDS-PAGE or MALDI-TOF MS profiles.Scientific reports · 2019Article
- Differences in distribution of MLS antibiotics resistance genes in clinical isolates of staphylococci belonging to species: S. epidermidis, S. hominis, S. haemolyticus, S. simulans and S. warneri.BMC microbiology · 2019Article
- Multifactorial mechanisms of the pathogenesis of methicillin-resistant Staphylococcus hominis isolated from bloodstream infections.Antonie van Leeuwenhoek · 2018Article
- Whole-Genome Sequence ofGenome announcements · 2017Article
- Draft Genome Sequences of Biosafety Level 2 Opportunistic Pathogens Isolated from the Environmental Surfaces of the International Space Station.Genome announcements · 2016Article
- Molecular basis of resistance to macrolides, lincosamides and streptogramins in Staphylococcus hominis strains isolated from clinical specimens.Folia microbiologica · 2016Article
- Antibiotic Susceptibility of Biofilm Cells and Molecular Characterisation of Staphylococcus hominis Isolates from Blood.PloS one · 2015Article
- Identifying gram-positive cocci in dermatoscopes and smartphone adapters using MALDI-TOF MS: a cross-sectional study.Anais brasileiros de dermatologiaArticle
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong Coagulase-Negative Staphylococci (CoNS), Staphylococcus hominis represents the third most common organism recoverable from the blood of immunocompromised patients. The aim of this study was to characterize biofilm formation, antibiotic resistance, define the SCCmec (Staphylococcal Chromosomal Cassette mec) type, and genetic relatedness of clinical S. hominis isolates. METHODOLOGY: S. hominis blood isolates (n = 21) were screened for biofilm formation using crystal violet staining. Methicillin resistance was evaluated using the cefoxitin disk test and the mecA gene was detected by PCR. Antibiotic resistance was determined by the broth microdilution method. Genetic relatedness was determined by pulsed-field gel electrophoresis (PFGE) and SCCmec typed by multiplex PCR using two different methodologies described for Staphylococcus aureus.
resultsOf the S. hominis isolates screened, 47.6% (10/21) were categorized as strong biofilm producers and 23.8% (5/21) as weak producers. Furthermore, 81% (17/21) of the isolates were methicillin resistant and mecA gene carriers. Resistance to ampicillin, erythromycin, and trimethoprim was observed in >70% of isolates screened. Each isolate showed a different PFGE macrorestriction pattern with similarity ranging between 0-95%. Among mecA-positive isolates, 14 (82%) harbored a non-typeable SCCmec type: eight isolates were not positive for any ccr complex; four contained the mec complex A ccrAB1 and ccrC, one isolate contained mec complex A, ccrAB4 and ccrC, and one isolate contained the mec complex A, ccrAB1, ccrAB4, and ccrC. Two isolates harbored the association: mec complex A and ccrAB1. Only one strain was typeable as SCCmec III.
conclusionsThe S. hominis isolates analyzed were variable biofilm producers had a high prevalence of methicillin resistance and resistance to other antibiotics, and high genetic diversity. The results of this study strongly suggested that S. hominis isolates harbor new SCCmec structural elements and might be reservoirs of ccrC1 in addition to ccrAB1 and mec complex A.
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