ArticlePloS one2013
Regulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer.Journal of cancer research and clinical oncology · 2023Article
- NRF2 and the Moirai: Life and Death Decisions on Cell Fates.Antioxidants & redox signaling · 2023Review
- Article
- Modulation of mouse laryngeal inflammatory and immune cell responses by low and high doses of mainstream cigarette smoke.Scientific reports · 2022Article
- Correlation between level of autophagy and frequency of CD8The Journal of international medical research · 2020Article
- Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles.Scientific reports · 2020Article
- Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis.Translational oncology · 2020Article
- Autophagy in chronic lung disease.Progress in molecular biology and translational science · 2020Review
- Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice.Redox report : communications in free radical research · 2019Article
- Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.FASEB bioAdvances · 2019Article
- Oxidative stress, autophagy and airway ion transport.American journal of physiology. Cell physiology · 2019Review
- Proteasome Inhibitor-Induced IκB/NF-κB Activation is Mediated by Nrf2-Dependent Light Chain 3B Induction in Lung Cancer Cells.Molecules and cells · 2018Article
- The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells.Redox biology · 2018Article
- Autophagy and inflammation in chronic respiratory disease.Autophagy · 2018Review
- Potential impact of oxidative stress induced growth inhibitor 1 (OSGIN1) on airway epithelial cell autophagy in chronic obstructive pulmonary disease (COPD).Journal of thoracic disease · 2017Article
- Dysregulated autophagy increased melanocyte sensitivity to HScientific reports · 2017Article
- Autophagy and airway fibrosis: Is there a link?F1000Research · 2017Review
- Differential regulation of autophagy and mitophagy in pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.Scientific reports · 2016Article
- Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.Frontiers in bioscience (Landmark edition) · 2016Review
Corrections and comments
- Correction · 2014-01-06Error in Text · · Article was later retracted; see also: https://pubpeer.com/publications/2A77E231CFD865658D3D3606D34BAA
- Retraction · 2023-08-25Duplication of/in Image · Manipulation of Images · Original Data and/or Images not Provided and/or not Available · · see also: https://pubpeer.com/publications/2A77E231CFD865658D3D3606D34BAA
- Erratum issuedBarret, Erika C [corrected to Barrett, Erika C]
- Retracted
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Cigarette smoke (CS) has been reported to induce autophagy in airway epithelial cells. The subsequent autophagic cell death has been proposed to play an important pathogenic role in chronic obstructive pulmonary disease (COPD); however, the underlying molecular mechanism is not entirely clear. Using CS extract (CSE) as a surrogate for CS, we found that it markedly increased the expressions of both LC3B-I and LC3B-II as well as autophagosomes in airway epithelial cells. This is in contrast to the common autophagy inducer (i.e., starvation) that increases LC3B-II but reduces LC3B-I. Further studies indicate that CSE regulated LC3B at transcriptional and post-translational levels. In addition, CSE, but not starvation, activated Nrf2-mediated adaptive response. Increase of cellular Nrf2 by either Nrf2 overexpression or the knockdown of Keap1 (an Nrf2 inhibitor) significantly repressed CSE-induced LC3B-I and II as well as autophagosomes. Supplement of NAC (a GSH precursor) or GSH recapitulated the effect of Nrf2, suggesting the increase of cellular GSH level is responsible for Nrf2 effect on LC3B and autophagosome. Interestingly, neither Nrf2 activation nor GSH supplement could restore the repressed activities of mTOR or its downstream effctor-S6K. Thus, the Nrf2-dependent autophagy-suppression was not due to the re-activation of mTOR-the master repressor of autophagy. To search for the downstream effector of Nrf2 on LC3B and autophagosome, we tested Nrf2-dependent genes (i.e., NQO1 and P62) that are also increased by CSE treatment. We found that P62, but not NQO1, could mimic the effect of Nrf2 activation by repressing LC3B expression. Thus, Nrf2->P62 appears to play an important role in the regulation of CSE-induced LC3B and autophagosome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.