ArticleHeart Asia2013
Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome.
Article in Heart Asia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Prior statin use and the incidence of in-hospital arrhythmia in acute coronary syndrome: A systematic review and meta-analysis.Indian heart journalPooled it
- Anti-arrhythmic properties of non-antiarrhythmic medications.Pharmacological research · 2020Review
- Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction.Molecular medicine reports · 2016Article
- Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Effects of atorvastatin on time-dependent change of fast sodium current in simulated acute ischaemic ventricular myocytes.Cardiovascular journal of AfricaArticle
Corrections and comments
- Erratum issuedCorrection.2013
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn addition to lowering cholesterol, statins stabilise atherosclerotic plaques and can potentially reduce the incidence of ventricular arrhythmias. We tested the hypothesis that prior statin therapy is associated with a lower incidence of inhospital ventricular arrhythmias among patients with acute coronary syndrome (ACS).
methodsThe study population consisted of 2007 patients (mean age 64 years, 67.5% male) enrolled in the Thai Registry of Acute Coronary Syndrome, a prospective, multicentre, nationwide, observational study of patients with ACS. Patients were categorised as either statin users or non-users according to their reports of statin use before enrolment at their initial presentation. The primary endpoint was inhospital ventricular arrhythmias. The secondary endpoint was a composite endpoint of inhospital ventricular arrhythmias or inhospital cardiac death. A propensity-adjusted multivariate model was developed to assess the effects of statin use on the primary and secondary endpoints.
resultsDuring a mean hospital stay of 7 days, a total of 96 patients (4.8%) died; 82 (4.1%) of the deaths were due to cardiac causes. The primary and secondary endpoints were reached in 163 patients (8.1%) and 194 patients (9.7%), respectively. A total of 525 patients (26.2%) had used statins prior to hospitalisation. After adjusting for the propensity scores and other relevant covariates, statin use was associated with lower risks of the primary (adjusted OR 0.505, 95% CI 0.276 to 0.923) and secondary endpoints (adjusted OR 0.498, 95% CI 0.276 to 0.897).
conclusionsThe use of statins is associated with a reduced incidence of ventricular arrhythmias among patients with ACS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.