Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2013
Can gestational hypertension be modified by treating nocturnal airflow limitation?
Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Positive Airway Pressure Treatment of Obstructive Sleep Apnea-Hypopnea in Hypertensive Disorders of Pregnancy: A Pilot Randomized Proof-of-Concept Clinical Trial.Annals of the American Thoracic Society · 2024Trial
- Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial.Respiratory research · 2023Trial
- Obstructive sleep apnea-associated hypertensive disorders in pregnancy: a literature review and clinical management strategies.Reproductive biology and endocrinology : RB&E · 2025Review
- Obstructive sleep apnea in pregnant women.International anesthesiology clinics · 2022Article
- The effect of continuous positive airway pressure treatment on hypertensive disorder in pregnant women with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Article
- Impact of nasal dilator strips on measures of sleep-disordered breathing in pregnancy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Associations Between Sleep Disorders and Hypertensive Disorders of Pregnancy and Materno-fetal Consequences.Current hypertension reports · 2020Review
- Treatment of superimposed preeclampsia on chronic hypertension in a twin pregnancy with automatic continuous positive airway pressure: a case report.BMC pulmonary medicine · 2020Article
- Sleep Disordered Breathing, a Novel, Modifiable Risk Factor for Hypertensive Disorders of Pregnancy.Current hypertension reports · 2020Review
- Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management.Anesthesia and analgesia · 2018Review
- Effects of maternal obstructive sleep apnea on fetal growth: a case-control study.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Association Between Sleep-Disordered Breathing and Hypertensive Disorders of Pregnancy and Gestational Diabetes Mellitus.Obstetrics and gynecology · 2017Article
- NuMoM2b Sleep-Disordered Breathing study: objectives and methods.American journal of obstetrics and gynecology · 2015Observational
- The cardiovascular, metabolic, fetal and neonatal effects of CPAP use in pregnant women: a systematic review.Sleep science (Sao Paulo, Brazil)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent evidence suggests that women with gestational hypertension (GH) have a high rate of sleep disordered breathing (SDB), and treatment for even marginal SDB may improve blood pressure control in women with GH. We assessed whether the application SDB treatment could improve blood pressure in women with GH.
methodsThis was a single-center randomized study. Subjects underwent an unattended home-based diagnostic sleep study. The study was then repeated with subjects wearing one of two randomly assigned treatments: auto-titrating continuous positive airway pressure (auto-CPAP) or mandibular advancement device (MAD) + nasal strip. First morning blood pressure and blood for standard GH measures plus inflammatory markers were taken after each study. Subjects completed a series of questionnaires addressing sleep quality and tolerance of assigned therapy.
resultsTwenty-four women completed the protocol-13 in the MAD group and 11 in auto-CPAP. The overall rate of SDB was 38%. Auto-CPAP was more effective at treating SDB than MAD + nasal strip, although the women randomized to MAD + nasal strip reported the greater comfort with therapy. First morning blood pressure was not consistently improved with either therapy. When subjects were stratified according to those whose blood pressure increased or decreased with therapy, an association was suggested between blood pressure improvement and reduced levels of tumour necrosis factor-α.
conclusionWe demonstrated that 38% of women with GH had concurrent SDB. We did not find an improvement in blood pressure or inflammatory markers with a single night of either the auto-CPAP or MAD + nasal strip interventions. However important lessons from this study may guide future investigations in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.