ArticlePLoS biology2013
Synthesis of very-long-chain fatty acids in the epidermis controls plant organ growth by restricting cell proliferation.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 150 citations in OpenAlex.
- A precise splice: proper splicing patterns required for appropriate lipid metabolism during callus induction with cytokinin.Plant physiology · 2026Article
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- Understanding Callus Types in Maize by Genetic Mapping and Transcriptional Profiling.Plants (Basel, Switzerland) · 2025Article
- Biosynthesis of very Long-chain fatty acids is required for Arabidopsis auxin-mediated embryonic and post-embryonic development.The Plant journal : for cell and molecular biology · 2025Article
- The WSD-type wax ester synthase is widely conserved in streptophytes and crucial for floral organ formation under high humidity in land plants.Journal of plant research · 2025Article
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- MYB74 transcription factor guides de novo specification of epidermal cells in the abscission zone of Arabidopsis.Nature plants · 2025Article
- Extranuclear function of Arabidopsis HOOKLESS1 regulates pleiotropic developmental processes in a non-cell-autonomous manner.The New phytologist · 2025Article
- Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism.The New phytologist · 2024Article
- The Ins and Outs of Homeodomain-Leucine Zipper/Hormone Networks in the Regulation of Plant Development.International journal of molecular sciences · 2024Review
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- TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua.Molecular horticulture · 2024Article
- Quantitative analysis of lateral root development with time-lapse imaging and deep neural network.Quantitative plant biology · 2024Article
- HD-Zip IV transcription factors: Drivers of epidermal cell fate integrate metabolic signals.Current opinion in plant biology · 2023Review
- Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana.The Plant cell · 2023Article
- Brassinosteroids regulate cotton fiber elongation by modulating very-long-chain fatty acid biosynthesis.The Plant cell · 2023Article
- DomesticatingFrontiers in plant science · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2022Article
- PUCHI represses early meristem formation in developing lateral roots of Arabidopsis thaliana.Journal of experimental botany · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant organ growth is controlled by inter-cell-layer communication, which thus determines the overall size of the organism. The epidermal layer interfaces with the environment and participates in both driving and restricting growth via inter-cell-layer communication. However, it remains unknown whether the epidermis can send signals to internal tissue to limit cell proliferation in determinate growth. Very-long-chain fatty acids (VLCFAs) are synthesized in the epidermis and used in the formation of cuticular wax. Here we found that VLCFA synthesis in the epidermis is essential for proper development of Arabidopsis thaliana. Wild-type plants treated with a VLCFA synthesis inhibitor and pasticcino mutants with defects in VLCFA synthesis exhibited overproliferation of cells in the vasculature or in the rib zone of shoot apices. The decrease of VLCFA content increased the expression of IPT3, a key determinant of cytokinin biosynthesis in the vasculature, and, indeed, elevated cytokinin levels. These phenotypes were suppressed in ipt3;5;7 triple mutants, and also by vasculature-specific expression of cytokinin oxidase, which degrades active forms of cytokinin. Our results imply that VLCFA synthesis in the epidermis is required to suppress cytokinin biosynthesis in the vasculature, thus fine-tuning cell division activity in internal tissue, and therefore that shoot growth is controlled by the interaction between the surface (epidermis) and the axis (vasculature) of the plant body.
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