ArticleIsrael journal of chemistry2011
Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain.
Article in Israel journal of chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Erythropoietin derived by chemical synthesis.Science (New York, N.Y.) · 2013Article
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last.Angewandte Chemie (International ed. in English) · 2013Review
- Advances in proline ligation.Journal of the American Chemical Society · 2012Article
- Synthetic glycopeptides and glycoproteins with applications in biological research.Beilstein journal of organic chemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We describe herein the assembly of hEPO(79-166), a key glycopeptide segment en route to erythropoietin, in minimally protected form. Key to the success of this synthetic endeavor was the application of our two-step cysteine-free native chemical ligation strategy, by which we achieved formal ligation at alanine and proline residues through the use of an N-terminal amino acid surrogate presenting a readily removable thiol functionality.
Identifiers
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Registered trials
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