ReviewThe Journal of clinical endocrinology and metabolism2013
Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation.
Review in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pentoxifylline for the treatment of endometriosis-associated pain and infertility.The Cochrane database of systematic reviews · 2021Pooled it
- Aromatase inhibitors for uterine fibroids.The Cochrane database of systematic reviews · 2013Pooled it
- Comparing efficacy and safety of stair step protocols for clomiphene citrate and letrozole in ovulation induction for women with polycystic ovary syndrome (PCOS): a randomized controlled clinical trial.Journal of medicine and life · 2023Trial
- Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility.The New England journal of medicine · 2015Trial
- Cardiotoxicity in breast cancer patients treated with chemoradiotherapy.Exploration of targeted anti-tumor therapy · 2026Review
- Exploring Microbiome-based Therapy: Bacterial Flavonoid Synthesis as a Novel Approach to PCOS Treatment.Current drug metabolism · 2026Review
- Anti‑inflammatory and anti‑migratory properties of wild‑grape‑derived ε‑viniferin in human endometrial cells: A potential therapy for endometriosis.Molecular medicine reports · 2025Article
- Comparison of Administration of Letrozole 20 mg Single Dose Versus 25 mg in Divided Doses to Stimulate Ovulation in IUI Cycles.Journal of obstetrics and gynaecology of India · 2025Article
- Reassessing the impact of letrozole co-administration in controlled ovarian hyperstimulation: findings from a single-center repeated measures study.Journal of assisted reproduction and genetics · 2024Article
- Expectant, Medical, and Surgical Management of Ovarian Endometriomas.Journal of clinical medicine · 2023Review
- Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival.Journal of ovarian research · 2022Article
- Observational
- Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease.Scientific reports · 2016Article
- Aromatase inhibitors in the treatment of endometriosis.Przeglad menopauzalny = Menopause review · 2016Review
- Oral Drugs for Unexplained Infertility.Journal of obstetrics and gynaecology of India · 2016Article
- The Estrogen Receptor-β Expression in De Quervain's Disease.International journal of molecular sciences · 2015Article
- Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.European journal of endocrinology · 2015Review
- Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution.Current opinion in obstetrics & gynecology · 2015Review
- The management of patients with polycystic ovary syndrome.Nature reviews. Endocrinology · 2014Review
- Potential role of aromatase inhibitors in the treatment of endometriosis.International journal of women's health · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
contextAnovulation is likely responsible for 20% of female infertility. Although clomiphene citrate remains the first-line therapy for ovulation induction in anovulatory patients who are not estrogen-deficient and to treat unexplained infertility, there remains a discrepancy between ovulation and conception rates with its use, attributed to its antiestrogenic effects on cervical mucus and the endometrium. Alternative agents, including aromatase inhibitors, have been used that have not been associated with these side effects. EVIDENCE ACQUISITION: A literature search was conducted to specifically explore the use of aromatase inhibitors for ovulation induction and superovulation. EVIDENCE SYNTHESIS: Recent studies have found that aromatase inhibitors may be safe and useful agents for ovulation induction in patients with polycystic ovarian syndrome as well a treatment option for superovulation in patients with either unexplained infertility or endometriosis.
conclusionsAromatase inhibitors may be an effective alternative treatment to clomiphene citrate for both ovulation induction and superovulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.