ArticleThe Plant cell2013
ACYL-LIPID DESATURASE2 is required for chilling and freezing tolerance in Arabidopsis.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Conserved mechanisms of plant lipidome remodeling under heat and cold stresses revealed through a systematic review and meta-analysis.Journal of experimental botany · 2026Pooled it
- Multiplex FAD2/FATB Editing Generates Ultra-High-Oleic, Low-Saturate Soybean With Increased Seed Fatty Acid Content.Plant biotechnology journal · 2026Article
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Natural photosynthetic system for restoring homeostasis of animal organelle interaction network.Nature communications · 2026Article
- Comparative assessment of food-grade osmolytes for enhancing yeast fermentation performance under salt stress.Microbiology spectrum · 2026Article
- Lipid Remodeling and Membrane Stability Contribute to Differential Chilling Tolerance in Two Dichondra (International journal of molecular sciences · 2026Article
- Article
- Genome-wide analysis of theFrontiers in plant science · 2025Article
- Genome-wide analysis of fatty acid desaturase genes in moso bamboo (Phyllostachys edulis) reveal their important roles in abiotic stresses responses.BMC genomics · 2024Article
- Rhythmic lipid and gene expression responses to chilling in panicoid grasses.Journal of experimental botany · 2024Article
- Adaptive traits of cysts of the snow alga Sanguina nivaloides unveiled by 3D subcellular imaging.Nature communications · 2023Article
- Plastid Phosphatidylglycerol Homeostasis Is Required for Plant Growth and Metabolism inMetabolites · 2023Article
- Physiological and Transcriptomic Analyses Revealed That Humic Acids Improve Low-Temperature Stress Tolerance in Zucchini (Plants (Basel, Switzerland) · 2023Article
- Effect of shading on physiological attributes and comparative transcriptome analysis ofFrontiers in plant science · 2023Article
- Genome-Wide Characterization and Expression Analysis of Fatty acid Desaturase Gene Family in Poplar.International journal of molecular sciences · 2022Article
- WRKY63 transcriptional activation of COOLAIR and COLDAIR regulates vernalization-induced flowering.Plant physiology · 2022Article
- Chromosome-level genome assembly of the diploid blueberry Vaccinium darrowii provides insights into its subtropical adaptation and cuticle synthesis.Plant communications · 2022Article
- Overexpression mutants reveal a role for a chloroplast MPD protein in regulation of reactive oxygen species during chilling in Arabidopsis.Journal of experimental botany · 2022Article
- An integrated analysis of the rice transcriptome and lipidome reveals lipid metabolism plays a central role in rice cold tolerance.BMC plant biology · 2022Article
- Genome-Wide Identification and Analysis ofInternational journal of molecular sciences · 2022Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acid desaturation of membrane lipids is a strategy for plants to survive chilling or freezing temperature. To further characterize enzymes involved in this stress response pathway, ACYL-LIPID DESATURASE2 (ADS2; Enzyme Commission 1.14.99) was studied using genetic, cell, and biochemical approaches. ads2 mutant plants appear similar to the wild type under standard growth conditions but display a dwarf and sterile phenotype when grown at 6°C and also show increased sensitivity to freezing temperature. Fatty acid composition analysis demonstrated that ads2 mutant plants at 6°C have reduced levels of 16:1, 16:2, 16:3, and 18:3 and higher levels of 16:0 and 18:0 fatty acids compared with the wild type. Lipid profiling revealed that 34C species of phosphatidylglycerol (PG) and monogalactosyl diacylglycerol (MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, lyso-phosphatidylcholine, and phosphatidylserine were higher than the wild type. Subcellular localization of C- and N-terminal enhanced fluorescence fusion proteins indicated that ADS2 localized primarily to the endoplasmic reticulum, although signal was also confirmed in Golgi and plastids. A double mutation with a putative plastid ADS3 paralog exacerbates the growth defects of ads2 mutant plants under low temperature. These observations suggest that ADS2 encodes a 16:0 desaturase of MGDG and PG. We hypothesize that a low temperature-induced shift from the plastid to endoplasmic reticulum pathway for membrane lipid biosynthesis is required for the cold stress response in Arabidopsis thaliana, and ADS2 is essential to adjust the acyl composition of organelle membrane lipid composition in response to cold stress.
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