ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Respiratory influences on muscle sympathetic nerve activity and vascular conductance in the steady state.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Eight weeks of device-guided slow breathing decreases sympathetic nervous reactivity to stress in posttraumatic stress disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Time sequence of autonomic changes induced by daily slow-breathing sessions.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Trial
- Improved exercise ventilatory efficiency with nasal compared to oral breathing in cardiac patients.Frontiers in physiology · 2024Article
- Acute nasal breathing lowers diastolic blood pressure and increases parasympathetic contributions to heart rate variability in young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome.American journal of physiology. Heart and circulatory physiology · 2023Article
- Sports Performance and Breathing Rate: What Is the Connection? A Narrative Review on Breathing Strategies.Sports (Basel, Switzerland) · 2023Review
- Cardiorespiratory dynamics during respiratory maneuver in athletes.Frontiers in network physiology · 2023Article
- Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception.Scientific reports · 2022Article
- A flexible adhesive surface electrode array capable of cervical electroneurography during a sequential autonomic stress challenge.Scientific reports · 2022Article
- Sympathetic neural reactivity to the Trier social stress test.The Journal of physiology · 2022Article
- Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans.Physiological reports · 2022Article
- The need for specificity in quantifying neurocirculatory vs. respiratory effects of eucapnic hypoxia and transient hyperoxia.The Journal of physiology · 2020Article
- Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Additional Improvement of Respiratory Technique on Vascular Function in Hypertensive Postmenopausal Women Following Yoga or Stretching Video Classes: The YOGINI Study.Frontiers in physiology · 2020Article
- Acute effects of resonance frequency breathing on cardiovascular regulation.Physiological reports · 2019Article
- Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology.Clinics in chest medicine · 2019Review
- Inhibiting the Physiological Stress Effects of a Sustained Attention Task on Shoulder Muscle Activity.International journal of environmental research and public health · 2018Observational
- The physiological effects of slow breathing in the healthy human.Breathe (Sheffield, England) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In patients with hypertension, volitional slowing of the respiratory rate has been purported to reduce arterial pressure via withdrawal of sympathetic tone. We examined the effects of paced breathing at 7, 14, and 21 breaths/min, with reciprocal changes in tidal volume, on muscle sympathetic nerve activity, forearm blood flow, forearm vascular conductance, and blood pressure in 21 men and women, 8 of whom had modest elevations in systemic arterial pressure. These alterations in breathing frequency and volume did not affect steady-state levels of sympathetic activity, blood flow, vascular conductance, or blood pressure (all P > 0.05), even though they had the expected effect on sympathetic activity within breaths (i.e., increased modulation during low-frequency/high-tidal volume breathing) (P < 0.001). These findings were consistent across subjects with widely varied baseline levels of sympathetic activity (4-fold), mean arterial pressure (78-110 mmHg), and vascular conductance (15-fold), and those who became hypocapnic during paced breathing vs. those who maintained normocapnia. These findings challenge the notion that slow, deep breathing lowers arterial pressure by suppressing steady-state sympathetic outflow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.