Evidence map›Paper›PMID 23584985›Full record

SynthesisImmunologic research2013

Novel risk factors for cardiovascular disease in rheumatoid arthritis.

Jenny Amaya-Amaya, Juan Camilo Sarmiento-Monroy, Ruben-Dario Mantilla, Ricardo Pineda-Tamayo, Adriana Rojas-Villarraga, Juan-Manuel Anaya

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Salivary Zinc Levels in Rheumatoid Arthritis.Journal of pharmacy & bioallied sciences · 2025
    Article
  4. In silico identification of compounds fromFrontiers in pharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
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  12. Review
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  15. Article
  16. Observational
  17. Article
  18. Expansions of Cytotoxic CD4Frontiers in immunology · 2017
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jenny Amaya-AmayaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63C-69, Bogotá, Colombia.
Juan Camilo Sarmiento-Monroy
Ruben-Dario Mantilla
Ricardo Pineda-Tamayo
Adriana Rojas-Villarraga
Juan-Manuel Anaya
Universidad del Rosario · COMunicipality of Medellín · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since cardiovascular disease (CVD) is the most common cause of mortality in patients with rheumatoid arthritis (RA), we aimed to determine factors associated with such a complication in a large series of Colombian patients. This was a cross-sectional analytical study in which 800 consecutive Colombian patients with RA were assessed for variables associated with CVD. Furthermore, a systematic literature review was performed to address the state of the art about non-traditional risk factors for CVD in RA. The preferred reporting items for systematic reviews and meta-analyses guidelines were followed in data extraction, analysis, and reporting of articles selected. Hypercholesterolemia, type 2 diabetes mellitus, abnormal body mass index, abdominal obesity, and current smoking were all traditional risk factors significantly associated with CVD in Colombians. As non-traditional risk factors, familial autoimmunity, more than 10 years of duration of the disease, patients working on household duties, use of systemic steroids, and low education level were associated with CVD in the studied population. Out of a total of 9,812 articles identified in PubMed and Scopus databases, 140 fulfilled the eligibility criteria and were included. Through this systematic review, several factors and outcomes related to CVD were confirmed and identified. These were categorized into genetics, RA-related, and others. Traditional risk factors do not completely explain the high rates of CVD in patients with RA; thus, novel risk factors related to autoimmunity are now recognized predicting the presence of CVD as strong as traditional risk factors. Our results may assist health professionals and policymakers in making decisions about CVD in patients with RA.

Indexed as

AdultAnimalsArthritis, RheumatoidAutoimmunityCardiovascular DiseasesColombiaCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseHumansHypercholesterolemiaMaleMiddle AgedObesityRisk Factors

Identifiers

PMID23584985
OpenAlexW1998623949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.