Observational studyClinical and experimental nephrology2014
Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome.
Observational study in Clinical and experimental nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- Beyond Proteinuria: Does Growth Matter in Childhood Nephrotic Syndrome?Indian journal of pediatrics · 2026Article
- Evaluation of thyroid profile among children aged 1-15 years with nephrotic syndrome: An observation study.World journal of clinical pediatrics · 2024Article
- Nonautoimmune overt hypothyroidism in the early stages of nephrotic syndrome: a case report from Somalia.Annals of medicine and surgery (2012) · 2023Article
- Thyroid function in patients with idiopathic nephrotic syndrome.International urology and nephrology · 2021Observational
- Severity of Proteinuria Is Directly Associated With Risk of Hypothyroidism in Adults.The Journal of clinical endocrinology and metabolism · 2021Article
- Prevalence of hypothyroidism in Japanese chronic kidney disease patients.Renal failure · 2020Article
- Changes in the thyroid hormone profiles in children with nephrotic syndrome.Korean journal of pediatrics · 2019Article
- A case of minimal change nephrotic syndrome with hypothyroidism deterioration.CEN case reports · 2016Article
- Do Not Forget Nephrotic Syndrome as a Cause of Increased Requirement of Levothyroxine Replacement Therapy.European thyroid journal · 2015Article
- Should all nephrotics with thyroid dysfunction be treated with levothyroxine?Pediatric nephrology (Berlin, Germany) · 2014Article
- The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications.Pediatric nephrology (Berlin, Germany) · 2014Review
- Outcomes of children with idiopathic steroid resistant nephrotic syndrome: a single centre observational study.Jornal brasileiro de nefrologiaArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid status has not been studied well in children with steroid resistant nephrotic syndrome (SRNS).
methodsIn this cross sectional study we recruited 20 children aged 1-16 years with SRNS and similar number of controls. Serum levels of FT3, FT4 and TSH were measured in all the subjects. Overt hypothyroidism was defined as low FT4 (normal values: 0.7-2.0 ng/mL) and elevated serum TSH above reference values (0.45-4.5 mIU/L). Subclinical hypothyroidism (SH) was defined as an elevation in serum TSH with a normal serum FT4 concentration. The primary outcome measure was serum levels of FT3, FT4 and TSH in children with SRNS.
resultsThirty per cent of the children (n = 6) with SRNS had non-autoimmune subclinical hypothyroidism (2 children each with grade I, II and III). Children with SRNS had a median TSH value [3.9 mIU/L (0.5-13)] within normal range, but levels were high as compared to controls. Out of 6 children with SH, 3 were in partial remission, 3 were in complete remission. The TSH levels normalized on thyroxine supplementation in grades II and III subclinical hypothyroidism.
conclusionSubclinical non-autoimmune hypothyroidism is present in a significant proportion of children with SRNS despite partial or complete remission. Thyroid profile should be evaluated routinely in this subset of patients.
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