Evidence map›Paper›PMID 23584881›Full record

ReviewClinical and experimental nephrology2013

Vasopressin and the regulation of aquaporin-2.

Justin L L Wilson, Carlos A Miranda, Mark A Knepper

Open access · greenAbstract readReview
In one paragraph

Review in Clinical and experimental nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 123 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025
    Article
  11. Article
  12. Syndrome of Inappropriate Antidiuresis.Journal of the American Society of Nephrology : JASN · 2025
    Review
  13. Article
  14. Review
  15. Renal interoception in health and disease.Autonomic neuroscience : basic & clinical · 2024
    Review
  16. Article
  17. Article
  18. Regulation of the water channel aquaporin-2 by cullin E3 ubiquitin ligases.American journal of physiology. Renal physiology · 2024
    Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Justin L L WilsonEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr., Bldg 10, Room 6N260, Bethesda, MD, 20892-1603, USA.
Carlos A Miranda
Mark A Knepper
National Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Solute And Water Transport In Renal EpitheliaZIAHL001285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2009 to 2025
$34.9M
Computational Tools for ProteomicsZIAHL006129 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2011 to 2025
$8.1M
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIAZ01HL001285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK A · 1998 to 2008
$3.8M
Urinary ExosomesZIAHL006128 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2011 to 2019
$354k
Intramural NIH HHS Z01 HL001285Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL001285Intramural NIH HHS ZIA HL006128Intramural NIH HHS ZIA HL006129
6 · The paper itself

Abstract

Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.

Indexed as

AnimalsAquaporin 2beta CateninCyclic AMPCyclic AMP-Dependent Protein KinasesHeart FailureHumansInappropriate ADH SyndromeKidney Tubules, CollectingLiver CirrhosisMiceMyosin-Light-Chain KinaseNephrotic SyndromePermeabilityPhosphoproteinsPhosphorylationAquaporin 2beta CateninCyclic AMPCyclic AMP-Dependent Protein KinasesMyosin-Light-Chain KinasePhosphoproteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-junTranscription Factor AP-1Transcription FactorsVasopressins

Identifiers

PMID23584881
PMCPMC3775849
OpenAlexW1974381270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.