Evidence map›Paper›PMID 23584841›Full record

ReviewAdvanced healthcare materials2013

Silicon micro- and nanofabrication for medicine.

Daniel Fine, Alessandro Grattoni, Randy Goodall, Shyam S Bansal, Ciro Chiappini, Sharath Hosali, Anne L van de Ven, Srimeenkashi Srinivasan, Xuewu Liu, Biana Godin and 8 more

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. RSC advances · 2021
    Article
  7. Article
  8. Review
  9. High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.Advanced materials (Deerfield Beach, Fla.) · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Daniel FineDepartment of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, USA. agrattoni@tmhs.org
Alessandro Grattoni
Randy Goodall
Shyam S Bansal
Ciro Chiappini
Sharath Hosali
Anne L van de Ven
Srimeenkashi Srinivasan
Xuewu Liu
Biana Godin
Louis Brousseau
Iman K Yazdi
Joseph Fernandez-Moure
Ennio Tasciotti
Hung-Jen Wu
Ye Hu
Steve Klemm
Mauro Ferrari
Houston Methodist · USNanoMedical Systems (United States) · USEcoHealth Alliance · USImperial College London · GBUniversity of Houston · US

Funding

Texas Center for Cancer NanomedicineU54CA151668 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2010 to 2014
$12.4M
TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CURLEY, STEVEN ALAN · 2009 to 2014
$10.8M
Nanovectors for Characterization and Destruction of Breast Tumor VasculatureR01CA128797 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2007 to 2010
$1.7M
Nanoparticles for Harvesting and Targeting Angiogenic ProteinsR33CA122864 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FERRARI, MAURO · 2008 to 2010
$1.1M
NCI NIH HHS 1U54CA151668-01NCI NIH HHS R01 CA128797NCI NIH HHS R01CA128797NCI NIH HHS R33 CA122864NCI NIH HHS R33CA122864NCI NIH HHS U54 CA143837NCI NIH HHS U54CA143837NCI NIH HHS U54 CA151668
6 · The paper itself

Abstract

This manuscript constitutes a review of several innovative biomedical technologies fabricated using the precision and accuracy of silicon micro- and nanofabrication. The technologies to be reviewed are subcutaneous nanochannel drug delivery implants for the continuous tunable zero-order release of therapeutics, multi-stage logic embedded vectors for the targeted systemic distribution of both therapeutic and imaging contrast agents, silicon and porous silicon nanowires for investigating cellular interactions and processes as well as for molecular and drug delivery applications, porous silicon (pSi) as inclusions into biocomposites for tissue engineering, especially as it applies to bone repair and regrowth, and porous silica chips for proteomic profiling. In the case of the biocomposites, the specifically designed pSi inclusions not only add to the structural robustness, but can also promote tissue and bone regrowth, fight infection, and reduce pain by releasing stimulating factors and other therapeutic agents stored within their porous network. The common material thread throughout all of these constructs, silicon and its associated dielectrics (silicon dioxide, silicon nitride, etc.), can be precisely and accurately machined using the same scalable micro- and nanofabrication protocols that are ubiquitous within the semiconductor industry. These techniques lend themselves to the high throughput production of exquisitely defined and monodispersed nanoscale features that should eliminate architectural randomness as a source of experimental variation thereby potentially leading to more rapid clinical translation.

Indexed as

Biocompatible MaterialsNanocapsulesNanomedicineSiliconTissue EngineeringBiocompatible MaterialsNanocapsulesSilicon

Identifiers

PMID23584841
PMCPMC3777663
OpenAlexW2166850691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.