ArticleSurgical endoscopy2013
Transluminal retroperitoneal endoscopic necrosectomy with the use of hydrogen peroxide and without external irrigation: a novel approach for the treatment of walled-off pancreatic necrosis.
Article in Surgical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Endoscopic transluminal necrosectomy in necrotising pancreatitis: a systematic review.Surgical endoscopy · 2014Pooled it
- Hydrogen peroxide-assisted endoscopic necrosectomy for walled-off pancreatic necrosis: a dual center pilot experience.Digestive diseases and sciences · 2014Trial
- Concentration-dependent effect of hydrogen peroxide on pancreatic necrosis: An ex vivo study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Review
- Common Practice of Percutaneous Drainage in Necrotising Pancreatitis-A Multicentre Retrospective Study (DRACULA).United European gastroenterology journal · 2025Article
- Chemical Necrosectomy for Infected Pancreatic Necrosis: Should We Get "High" On Alcohol?Digestive diseases and sciences · 2024Article
- Minimally invasive surgery compared to endoscopic intervention for treating infected pancreatic necrosis. A meta-analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Efficacy and Safety of Anhydrous Ethanol-Assisted Endoscopic Ultrasound-Guided Transluminal Necrosectomy in Infected Necrotizing Pancreatitis.Digestive diseases and sciences · 2024Observational
- Endoscopic therapies for walled-off necrosis.iGIE : innovation, investigation and insights · 2023Article
- Endoscopic transluminal drainage and necrosectomy for infected necrotizing pancreatitis: Progress and challenges.World journal of clinical cases · 2023Review
- Direct Endoscopic Necrosectomy: Timing and Technique.Medicina (Kaunas, Lithuania) · 2021Review
- Endoscopic Transmural Drainage and Necrosectomy in Acute Necrotizing Pancreatitis: A Review.Journal of translational internal medicine · 2021Article
- Management of walled-off necrosis with nasocystic irrigation with hydrogen peroxide versus biflanged metal stent: randomized controlled trial.Endoscopy international open · 2021Article
- Article
- The role of endoscopic therapy in the minimally invasive management of pancreatic necrosis.The Korean journal of internal medicine · 2021Review
- International, multicenter retrospective trial comparing the efficacy and safety of bi-flanged versus lumen-apposing metal stents for endoscopic drainage of walled-off pancreatic necrosis.Annals of gastroenterology · 2021Article
- Preliminary report on the safety and utility of a novel automated mechanical endoscopic tissue resection tool for endoscopic necrosectomy: a case series.Endoscopy international open · 2020Article
- Endoscopic Management of Acute Biliopancreatic Disorders.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Review
- Lumen apposing metal stents are superior to plastic stents in pancreatic walled-off necrosis: a large international multicenter study.Endoscopy international open · 2019Article
- Endotherapy for pancreatic necrosis: An update.JGH open : an open access journal of gastroenterology and hepatology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransluminal retroperitoneal endoscopic necrosectomy (TREN) is an attractive NOTES technique alternative to surgery for treatment of walled-off pancreatic necrosis (WOPN). The main limitations to this technique are the need for repeated sessions, prolonged external irrigation, and EUS availability. In our study, we introduced new modifications, including the use of hydrogen peroxide, and abandoning the use of EUS and external irrigation.
methodsThis is a retrospective study of outcome of consecutive patients who underwent TREN for WOPN between April 2011 and August 2012. The technique included (1) non-EUS-guided transluminal drainage, and (2) direct endoscopic debridement using hydrogen peroxide and different accessories. No external irrigation was used.
resultsTen patients were included. Initial clinical and technical success was achieved in all patients. Complete radiological success and long-term clinical efficacy was achieved in nine patients (1 patient had an inaccessible left paracolic gutter collection and died 62 days after endotherapy). Mean number of sessions was 1.4 (range 1-2). Complications included bleeding, which was self-limited in three patients and endoscopically controlled in one. All patients avoided surgery, and no recurrence was reported during median follow-up of 289 (range 133-429) days.
conclusionsTREN is a safe and effective treatment for WOPN and could be performed safely without EUS guidance in selected cases. Hydrogen peroxide played a major role in reduction of number of sessions and timing. External irrigation of WOPN is not necessary, if adequate debridement could be achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.